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Nucleoporin 43

Nucleoporin 43 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Nucleoporin 43 rather than just read about it. In short: Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene. Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope.

Nucleoporin 43 — main illustration
Nucleoporin 43 — illustration

Key takeaways

  • Nucleoporin 43 belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect Nucleoporin 43 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of Nucleoporin 43 from memory before moving on to harder problems.

Reference excerpt

Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene. Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004).[supplied by OMIM] Along with other nucleoporins.

Structure It folds into a canonical WD40 repeat domain.

Disease association High expression of NUP43 in breast cancer is associated with poor overall survival. In chronic myelogenous leukemia (CML), reduction of miRNA-409-5p increases the expression of NUP43 that in turn enhances proliferative potential, cell cycle progression, and imatinib resistance. Some Nup43 variants have been characterized as causal for the onset of cardiovascular disease (CVD), while Nup43 expression has been associated with attention deficit hyperactivity disorder.

References

Further reading

External links Overview of all the structural information available in the PDB for UniProt: Q8NFH3 (Human Nucleoporin Nup43) at the PDBe-KB.

Illustrations

Nucleoporin 43 illustration
Nucleoporin 43 illustration
Nucleoporin 43 illustration
Nucleoporin 43 illustration
Nucleoporin 43 illustration

Worked examples

Example 1 — a first encounter with Nucleoporin 43

Start with the simplest possible case. Write down what Nucleoporin 43 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Nucleoporin 43 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Nucleoporin 43 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Nucleoporin 43

In research
Nucleoporin 43 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses Nucleoporin 43 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
Nucleoporin 43 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 6, Human chromosome 6 gene stubs, Nuclear pore complex, so understanding it makes those chapters shorter.
In everyday life
Look for Nucleoporin 43 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study Nucleoporin 43 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what Nucleoporin 43 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain Nucleoporin 43 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Nucleoporin 43 in simple terms?

Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene. Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope.

Why does Nucleoporin 43 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Nucleoporin 43?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Nucleoporin 43.

Tags

  • Genes on human chromosome 6
  • Human chromosome 6 gene stubs
  • Nuclear pore complex

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