OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene.
Function This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.
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Further reading
External links Overview of all the structural information available in the PDB for UniProt: Q96G74 (Human OTU domain-containing protein 5) at the PDBe-KB. This article incorporates text from the United States National Library of Medicine, which is in the public domain.





