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Odapipam

Odapipam is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Odapipam rather than just read about it. In short: Odapipam (INNTooltip International Nonproprietary Name; developmental code names NNC 01-0756, NNC-756, NO-756) is a selective D1 receptor antagonist of the benzazepine group which was investigated as a potential antipsychotic but was never marketed. It has more than 5,000-fold selectivity for the dopamine D1 receptor (Ki = 0.17 nM) over the dopamine D2 receptor (Ki = 942 nM).

Odapipam — main illustration
Odapipam — illustration

Key takeaways

  • Odapipam belongs to science; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect Odapipam to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of Odapipam from memory before moving on to harder problems.

Reference excerpt

Odapipam (INNTooltip International Nonproprietary Name; developmental code names NNC 01-0756, NNC-756, NO-756) is a selective D1 receptor antagonist of the benzazepine group which was investigated as a potential antipsychotic but was never marketed. It has more than 5,000-fold selectivity for the dopamine D1 receptor (Ki = 0.17 nM) over the dopamine D2 receptor (Ki = 942 nM). Its affinities for other dopamine receptors, such as the dopamine D5 receptor, were not reported. In addition to the dopamine D1 receptor, odapipam showed relatively high affinity for the serotonin 5-HT2 receptor (Ki = 4.5 nM; 26-fold lower than for the D1 receptor). The drug was first described in the scientific literature by 1988.

See also Substituted 3-benzazepine List of investigational antipsychotics Berupipam (NNC 22-0010) Ecopipam (SCH-39166) NNC 01-0687 (ADX-10061) SCH-23390

References

Illustrations

Odapipam illustration

Worked examples

Example 1 — a first encounter with Odapipam

Start with the simplest possible case. Write down what Odapipam claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Odapipam before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Odapipam ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Odapipam

In research
Odapipam appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses Odapipam in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
Odapipam is common in secondary-school and first-year university syllabi. It links to neighbouring topics 5-HT2 antagonists, Abandoned drugs, Benzazepines, so understanding it makes those chapters shorter.
In everyday life
Look for Odapipam outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study Odapipam in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what Odapipam means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain Odapipam out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Odapipam in simple terms?

Odapipam (INNTooltip International Nonproprietary Name; developmental code names NNC 01-0756, NNC-756, NO-756) is a selective D1 receptor antagonist of the benzazepine group which was investigated as a potential antipsychotic but was never marketed. It has more than 5,000-fold selectivity for the d…

Why does Odapipam matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Odapipam?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Odapipam.

Tags

  • 5-HT2 antagonists
  • Abandoned drugs
  • Benzazepines
  • Benzofurans
  • Chloroarenes
  • D1 antagonists
  • Experimental drugs developed for schizophrenia
  • Hydroxyarenes
  • Psychoactive drug stubs

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