physics

Oleg Vladimirovich Krasilnikov

Oleg Vladimirovich Krasilnikov is a physics topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Oleg Vladimirovich Krasilnikov rather than just read about it. In short: Oleg Vladimirovich Krasilnikov (14 September 1950 – 30 August 2011) was a Soviet-born biophysicist who lived and worked in Uzbekistan and Brazil. His father, Vladimir Sergeyevich Krasilnikov, was a mining engineer who worked in the coal mines of Kyrgyzstan (Sulukta and Tash Kumyr).

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Reference excerpt

Oleg Vladimirovich Krasilnikov (14 September 1950 – 30 August 2011) was a Soviet-born biophysicist who lived and worked in Uzbekistan and Brazil. His father, Vladimir Sergeyevich Krasilnikov, was a mining engineer who worked in the coal mines of Kyrgyzstan (Sulukta and Tash Kumyr). His mother, Ekatherine Yakovlevna Krasilnikova, was an economist.

Education Oleg Vladimirovich Krasilnikov received his M.S. in biophysics from Tashkent State University(TashGU)(now National University of Uzbekistan) (1973), Uzbekistan). He completed his Ph.D. in biophysics at the Uzbekistan Institute of Biochemistry (The Academy of Sciences of Uzbekistan)(1977). His Ph.D. thesis was devoted to the subject “The influence of cytotoxin and phospholipase of Central Asian cobra venom on artificial and natural membranes.” And a D.Sci in biophysics was defended by the topic “Protein channels in a lipid bilayer” from Moscow State University of the Russian Academy of Sciences (1983).

Career Krasilnikov began his career in 1973 as a researcher at the Institute of Biochemistry of Uzbekistan in Tashkent. In 1992, he joined the Institute of Physiology and Biophysics at the Academy of Sciences of Uzbekistan (ASU) and in 1989 became the Chief of the Laboratory of Molecular Physiology at this institute. He was awarded the title of Full Professor in 1993. Krasilnikov moved to Recife, Brazil in 1993 as a visiting researcher of CAPES, then - CNPq, at the Federal University of Pernambuco (UFPE). In 1998, he joined the Biophysics and Radiobiology Department as a visiting professor. The following year he became the Chief of the Biological Membrane Laboratory, where he promoting research until 2011. In Brazil, Krasilnikov studied the Portuguese language and began to use it in lectures for undergraduate and graduate students. Starting in 2002, he regularly taught biophysics at UFPE, where he was awarded the title of Professor Titular in 2011. He was a member of the Biophysical Societies of Brazil and the United States. He held fellowships from the Brazilian National Council for Scientific and Technological Development (CNPq) for many years. Krasilnikov authored more than 100 scientific papers, published in international journals, plus one monograph, and two patents. He participated in many international meetings and chaired some workshops. After 1981, his laboratory became known for experiments on channels induced in membranes by bacterial pore-forming toxins of the Staphylococcus aureus, Bacillus cereus, Shigella, Pasteurella - reconstituted in planar lipid bilayers (principally α-staphylotoxin because of its unique ability to recognize polymer molecules that passed through it, that was used later by Oxford Nanopore technologies for DNA nanopore sequencing). His research was strongly based on the study of the pore-forming transmembrane proteins. He developed new experimental methods to study internal physical properties and geometry of functioning ion channels (diameter, internal structure). His group developed a method of sizing ion channels by comparing them with the diameters of known polymers - polyethylene glycols (nonelectrolyte exclusion method). The diameters of the functioning toxins such as Bacillus anthracis, Staphylococcus aureus, Cholera toxin and others were measured. This line of research served as the basis for development of new approaches to study functional ion channels in vitro and in vivo using patch-clamp assays. Krasilnikov mentored 10 Ph.D. students, 1 Dr. Sci student, and 26 M.S. students in Biophysics. Two conferences dedicated to him - "Electrophysiology — theory and practice" - were held at the Biological Center of the Federal University of Pernambuco (CCB, UFPE) in 2013 and 2014. The h-index for his publications is 21.

See also Lipid bilayer Transmembrane protein Patch clamp Pore-forming toxin

References

Further reading "Canais iônicos, pesquisa basca e saúde" [Ion channels, Basque research and health]. Jornal do Comércio (in Portuguese). Pernambuco. 12 December 2003. p. 7. "In memory of Oleg Vladimirovich Krasilnikov", Uzbek Biological Journal, 2012, N1, p. 54-55. Robertson, Joseph W. F.; Rodrigues, Claudio G.; Stanford, Vincent M.; Rubinson, Kenneth A.; Krasilnikov, Oleg V.; Kasianowicz, John J. (15 May 2007). "Single-molecule mass spectrometry in solution using a solitary nanopore". Proceedings of the National Academy of Sciences of the United States of America. 104 (20): 8207–8211. Bibcode:2007PNAS..104.8207R. doi:10.1073/pnas.0611085104. PMC 1866312. PMID 17494764.

External links "recife2011". recife2011.livejournal.com. Retrieved 10 September 2017. "Журналы Академии наук Узбекистана". Old.academy.uz. Archived from the original on 26 February 2017. Retrieved 10 September 2017. https://www.escavador.com/sobre/445939/oleg-vladimirovich-krasilnikov Search Results for author Krasil'nikov OV on PubMed. "PRIME PubMed - Free PubMed Journal Article Search". Unboundmedicine.com. Retrieved 10 September 2017. https://patents.google.com/patent/US20100122907A1/en https://patents.google.com/patent/WO2013026123A1/it

Illustrations

Worked examples

Example 1 — a first encounter with Oleg Vladimirovich Krasilnikov

Start with the simplest possible case. Write down what Oleg Vladimirovich Krasilnikov claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In physics, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Oleg Vladimirovich Krasilnikov before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Oleg Vladimirovich Krasilnikov ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Oleg Vladimirovich Krasilnikov

In research: Oleg Vladimirovich Krasilnikov appears in physics research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Oleg Vladimirovich Krasilnikov in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Oleg Vladimirovich Krasilnikov is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1950 births, 2011 deaths, Academic staff of the Federal University of Pernambuco, so understanding it makes those chapters shorter.
In everyday life: Look for Oleg Vladimirovich Krasilnikov outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

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Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

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