An orphan virus is a virus that is not associated with a disease but may possess pathogenicity. Gilbert Dalldorf, a pathologist who showed that Coxsackie viruses paralyze mice but not humans, indicated that the term ‘orphan’ was created "in a moment of conviviality" by a group of virologists. Many enteroviruses are referred to as ECHO, enteric cytopathic human orphan viruses, because they were originally not associated with any disease.
See also Novel virus Reoviridae Viral metagenomics
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