The Oslo study (1891–1910) was an observational study of untreated syphilis at Oslo University Hospital, Rikshospitalet in Oslo, Norway. Under the supervision of the department head, Cæsar Boeck, treatment was withheld from approximately 2,000 patients with syphilis between the period of 1891 and 1910. The results of Boeck's patient observations were later documented by his successor Edvin Bruusgaard in the paper "The Fate of Syphilitics who had received no Specific Treatment" (1929). The results of the study greatly influenced American researchers who conducted the Tuskegee Syphilis Study (1932–1972), in which treatment was withheld from African American men with syphilis.
Background In the 18th century, the standard treatment for syphilis was mercury, typically in the form of mercuric chloride, because it was believed that the sweating and salivation caused by mercury would help patients purge harmful substances from their bodies. As the effects of mercury poisoning became increasingly well documented in 19th century, many physicians began to reject mercury as a cure. Due to rapid urbanization and poverty, the number of syphilis cases in Norway rose during the 1870s and 1880s. Economic conditions also contributed to the growth of Norway's prostitution industry. In an attempt to curb the spread of syphilis, prostitutes were arrested and subjected to public medical examinations. Those found to have symptoms of syphilis were involuntarily sent to hospitals for treatment.
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