science

PF-06655075

PF-06655075 is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand PF-06655075 rather than just read about it. In short: PF-06655075, also known as PF1 or as ASK1476, is a peripherally selective long-acting peptide oxytocin receptor agonist which is used in scientific research. It is a lipidated analogue of oxytocin with dramatically enhanced metabolic stability and increased oxytocin receptor selectivity.

Key takeaways

PF-06655075 belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect PF-06655075 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of PF-06655075 from memory before moving on to harder problems.

Reference excerpt

PF-06655075, also known as PF1 or as ASK1476, is a peripherally selective long-acting peptide oxytocin receptor agonist which is used in scientific research. It is a lipidated analogue of oxytocin with dramatically enhanced metabolic stability and increased oxytocin receptor selectivity. PF-06655075 is a highly potent near-full agonist of the oxytocin receptor with similar affinity and potency as oxytocin itself (Ki = 0.037 nM; EC50Tooltip half-maximal effective concentration = 0.025 nM; EmaxTooltip maximal efficacy = 90%) and to a much lesser extent is an antagonist of the vasopressin V1A receptor (Ki = 4.37 nM; EC50 = >1,000 nM). It is also a potent agonist of the vasopressin V2 receptor (EC50 = 0.36 nM), with about 14-fold lower activational potency than at the oxytocin receptor. The drug has been found to inhibit conditioned fear-induced freezing behavior and anxiety in rodents when given either centrally or peripherally. It has been found to decrease alcohol consumption when given centrally but not peripherally in rodents. In addition, PF-06655075 robustly reduced food intake and body weight when given peripherally in rodents similarly to oxytocin but with less frequent and more convenient administration. Whereas oxytocin itself has an extremely short plasma elimination half-life, for instance 2 to 4 minutes in humans and 7 minutes in rats, PF-06655075 showed had a half-life of 8.5 hours by intravenous injection in rats. Non-depot subcutaneous injection resulted in an oxytocin half-life of 0.5 hours and a PF-06655075 half-life of 3.2 hours, whereas depot subcutaneous injection gave an oxytocin half-life of 7.3 hours and a PF-06655075 half-life of 309 hours. Both oxytocin and PF-06655075 are highly peripherally selective, with oxytocin showing a brain-to-plasma ratio of approximately 1% and PF-06655075 showing a ratio of about 2%. Unlike oxytocin, which is not highly bound to plasma proteins, PF-06655075 shows high plasma protein binding, and this is involved in its resistance to metabolism and longer duration. The chemical synthesis of PF-06655075 has been described. An analogue of PF-06655075, PF-06478939 (PF2), has also been described. PF-06655075 was developed by Pfizer for use as a tool in scientific research and was first described in the scientific literature by 2016.

See also Oxytocin receptor agonist OT-12

References

Worked examples

Example 1 — a first encounter with PF-06655075

Start with the simplest possible case. Write down what PF-06655075 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to PF-06655075 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about PF-06655075 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of PF-06655075

In research: PF-06655075 appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses PF-06655075 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: PF-06655075 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Cyclic peptides, Drugs not assigned an ATC code, Nonapeptides, so understanding it makes those chapters shorter.
In everyday life: Look for PF-06655075 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study PF-06655075 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what PF-06655075 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain PF-06655075 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is PF-06655075 in simple terms?

Why does PF-06655075 matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study PF-06655075?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on PF-06655075.