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PHF21A

PHF21A is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand PHF21A rather than just read about it. In short: PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene. Function BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM] Interactions PHF21A has bee…

PHF21A — main illustration
PHF21A — illustration

Key takeaways

  • PHF21A belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect PHF21A to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of PHF21A from memory before moving on to harder problems.

Reference excerpt

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.

Function BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM]

Interactions PHF21A has been shown to interact with:

HDAC1, HMG20B, Histone deacetylase 2, and RCOR1.

References

Further reading

External links PHF21A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Illustrations

PHF21A illustration
PHF21A illustration
PHF21A illustration
PHF21A illustration
PHF21A illustration

Worked examples

Example 1 — a first encounter with PHF21A

Start with the simplest possible case. Write down what PHF21A claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to PHF21A before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about PHF21A ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of PHF21A

In research
PHF21A appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses PHF21A in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
PHF21A is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 11, Human chromosome 11 gene stubs, Transcription factors, so understanding it makes those chapters shorter.
In everyday life
Look for PHF21A outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study PHF21A in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what PHF21A means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain PHF21A out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is PHF21A in simple terms?

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene. Function BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor e…

Why does PHF21A matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study PHF21A?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on PHF21A.

Tags

  • Genes on human chromosome 11
  • Human chromosome 11 gene stubs
  • Transcription factors

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