Phosphoinositide 3-kinase regulatory subunit 6 (also called p87PIKAP) is a protein that in humans is encoded by the PIK3R6 gene. The PIK3R6 protein is a regulatory subunit of phosphoinositide 3-kinase-γ (PI3Kγ), which functions as an enzyme (a lipid kinase) that is activated by membrane receptors. PIK3R6 is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils. It is also referred to as p84 and p87. Some studies have found PIK3R6 to have a role in carcinogenesis.
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