Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene. The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. PRB4 is post-translationally cleaved into three different mature peptides:
Protein N1 Glycosylated protein A Peptide P-D (also known as proline-rich peptide IB-5)
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