Pregnancy-specific beta-1-glycoprotein 2 is a protein that in humans is encoded by the PSG2 gene.
Structure Molecular cloning and analysis of several PSG genes has shown that PSG forms a subset of the carcinoembryonic antigen (CEA) gene family that belongs to the immunoglobulin superfamily genes. Members of the CEA family consist of a single N domain structurally similar to the immunoglobulin variable domain, followed by a variable number of constant immunoglobulin-like A and/or B domains. Most PSGs have the Argglyasp (RGD) motif in the N-terminal domain.
Function Human pregnancy-specific glycoproteins (PSGs) are a family of proteins synthesized in large quantities by the placental trophoblast and released into the maternal circulation during pregnancy. PSG2 has been shown to act as an adhesion recognition signal for some integrins.
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