In biology, the PYLIS downstream sequence (PYLIS: pyrrolysine insertion sequence) is a stem-loop structure that appears on some mRNA sequences. This structural motif was previously thought to cause the UAG (amber) stop codon to be translated to the amino acid pyrrolysine instead of ending the protein translation. However, it has been shown that PYLIS has no effect upon the efficiency of the UAG suppression, hence even its name is, in fact, incorrect.
See also SECIS element
References
Further reading Longstaff DG, Blight SK, Zhang L, Green-Church KB, Krzycki JA (January 2007). "In vivo contextual requirements for UAG translation as pyrrolysine". Mol. Microbiol. 63 (1): 229–241. doi:10.1111/j.1365-2958.2006.05500.x. PMID 17140411. S2CID 25346794. Theil Have, C; Zambach, S; Christiansen, H (April 4, 2013). "Effects of using coding potential, sequence conservation and mRNA structure conservation for predicting pyrrolysine containing genes". BMC Bioinformatics. 14 (1): 118. doi:10.1186/1471-2105-14-118. PMC 3639795. PMID 23557142.
External links
Page for Pyrrolysine insertion sequence 1 at Rfam