In enzymology, a pantothenase (EC 3.5.1.22) is an enzyme that catalyzes the chemical reaction
(R)-pantothenate + H2O ⇌ {\displaystyle \rightleftharpoons } (R)-pantoate + beta-alanine Thus, the two substrates of this enzyme are (R)-pantothenate and H2O, whereas its two products are (R)-pantoate and beta-alanine. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (R)-pantothenate amidohydrolase. Other names in common use include pantothenate hydrolase, and pantothenate amidohydrolase. This enzyme participates in pantothenate and coa biosynthesis.
References
Nurmikko V, Salo E, Hakola H, Makinen K, Snell EE (1966). "The bacterial degradation of pantothenic acid. II. Pantothenate hydrolase". Biochemistry. 5 (2): 399–402. doi:10.1021/bi00866a002. PMID 5940928.
