Parathyroid hormone 2 (or PTH2), also called TIP39, is a protein that in humans is encoded by the PTH2 gene. Parathyroid hormone 2 is related to parathyroid hormone and parathyroid hormone-related protein and is a ligand for the parathyroid hormone 2 receptor (PTH2R). The molecular interaction of PTH2 with the PTH2R has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding Expression of PTH2 has been linked to social interaction in both zebrafish and rats. In these species, mutations of PTH2 or PTH2R lead to abnormal social behavior.
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