biology

Patrick D'Silva

Patrick D'Silva is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Patrick D'Silva rather than just read about it. In short: Patrick D'Silva is an Indian cell biologist, biochemist, and an associate professor at the Molecular Chaperone Lab of the Indian Institute of Science. He is known for his medical discoveries related to neurodegenerative diseases and cancer biology.

Key takeaways

Patrick D'Silva belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Patrick D'Silva to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Patrick D'Silva from memory before moving on to harder problems.

Reference excerpt

Patrick D'Silva is an Indian cell biologist, biochemist, and an associate professor at the Molecular Chaperone Lab of the Indian Institute of Science. He is known for his medical discoveries related to neurodegenerative diseases and cancer biology. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2014.

Professional profile

Patrick D'Silva serves as an associate professor at the Division of Biological Sciences of the Indian Institute of Science and heads the Molecular Chaperone Lab as its principal investigator. His research focus is on the cell biological aspects of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease as well as various cancers and his team is known to have made several breakthroughs in the treatment of such diseases. In 2015, D'Silva led a research which identified that Hsp31, a stress response chaperone, in Yeast provided abiotic stress tolerance to the fungus. On further studies, he found out that the chaperone acts as a detoxifier by removing a toxic metabolite named Methylglyoxal (MG) and regulates reactive oxygen species (ROS). This led to further investigations and DJ-1, a protein similar to Hsp31, helped to enhance natural detoxifiers such as glutathione (GSH) which in turn regulated the reactive oxygen species and this discovery promised to offer new ways in the management of some forms of Parkinson's disease. Later, D'Silva and his team furthered their research and developed a metal oxide nanomaterial, which when introduced into humans, acted similar to three major cellular antioxidant enzymes which regulated the level of reactive oxygen species inside cells. This nanomaterial, made of vanadia, exhibited glutathione peroxidase enzyme activity, thus proving to be a nanozyme and it was the first time identification that all three major antioxidant enzymes in one nanozyme. This discovery is reported to have uses in drug development in cardiac disorders, and neurodegenrative diseases like Parkinson's and Alzheimer's disease. D'Silva's studies have been documented by way of a number of articles and ResearchGate, an online repository of scientific articles has listed 57 of them. He also hosts several post-doctoral and doctoral researchers at his laboratory.

Awards and honors The Department of Biotechnology (DBT) of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards in 2014. In 2016, D'Silva received the CDRI Award for Excellence in Drug Research from the Central Drug Research Institute.

Selected bibliography Singh, Namrata; Savanur, Mohammed Azharuddin; Srivastava, Shubhi; D'Silva, Patrick; Mugesh, Govindasamy (4 October 2017). "A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model". Angewandte Chemie International Edition. 56 (45): 14267–14271. doi:10.1002/anie.201708573. PMID 28922532. Melvin, Prasad; Bankapalli, Kondalarao; D’Silva, Patrick; Shivaprasad, P. V. (1 July 2017). "Methylglyoxal detoxification by a DJ-1 family protein provides dual abiotic and biotic stress tolerance in transgenic plants". Plant Molecular Biology. 94 (4–5): 381–397. doi:10.1007/s11103-017-0613-9. PMID 28444544. S2CID 22522772. Vernekar, Amit A.; Sinha, Devanjan; Srivastava, Shubhi; Paramasivam, Prasath U.; D’Silva, Patrick; Mugesh, Govindasamy (21 November 2014). "An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires". Nature Communications. 5: 5301. Bibcode:2014NatCo...5.5301V. doi:10.1038/ncomms6301. PMID 25412933.

Illustrations

Worked examples

Example 1 — a first encounter with Patrick D'Silva

Start with the simplest possible case. Write down what Patrick D'Silva claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Patrick D'Silva before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Patrick D'Silva ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Patrick D'Silva

In research: Patrick D'Silva appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Patrick D'Silva in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Patrick D'Silva is common in secondary-school and first-year university syllabi. It links to neighbouring topics Academic staff of the Indian Institute of Science, Indian biochemists, Indian cell biologists, so understanding it makes those chapters shorter.
In everyday life: Look for Patrick D'Silva outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “Patrick D'Silva” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Patrick D'Silva in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Patrick D'Silva means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Patrick D'Silva out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Patrick D'Silva in simple terms?

Why does Patrick D'Silva matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Patrick D'Silva?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Patrick D'Silva.