biology

Patrizia Paterlini-Bréchot

Patrizia Paterlini-Bréchot is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Patrizia Paterlini-Bréchot rather than just read about it. In short: Patrizia Paterlini-Bréchot, born in the Italian city of Reggio Emilia, is an Italian scientist and a professor of cell biology and oncology working at the Faculté de Médecine Necker-Enfants Malades, Université Paris Descartes and at INSERM in Paris. Education Patrizia Paterlini-Bréchot studied medicine at the University of Modena and Reggio Emilia, Italy.

Key takeaways

Patrizia Paterlini-Bréchot belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Patrizia Paterlini-Bréchot to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Patrizia Paterlini-Bréchot from memory before moving on to harder problems.

Reference excerpt

Patrizia Paterlini-Bréchot, born in the Italian city of Reggio Emilia, is an Italian scientist and a professor of cell biology and oncology working at the Faculté de Médecine Necker-Enfants Malades, Université Paris Descartes and at INSERM in Paris.

Education Patrizia Paterlini-Bréchot studied medicine at the University of Modena and Reggio Emilia, Italy. In 1978, she defended a thesis on Hodgkin's Lymphoma, which was awarded the title of « Best medical thesis » of the year 1978. She pursued her training and validated a double specialization in Hematology (1981), awarded the prize of « Best research in Hematology » of the year 1979, and in Oncology (1984). Patrizia Paterlini-Bréchot obtained a permanent academic position in the University of L'Aquila (1981), then Bologna (1984) working in the departments of Hematology, Gastroenterology and Oncology. In 1988 she moved to Paris (France) for a training in molecular biology in professor Christian Bréchot's laboratory. In 1993, she defended her PhD thesis, Fundamental bases of oncogenesis at University of Paris XI. She quit her academic position in the University of Bologna in 1993 and in 1994 she obtained an equivalent position in Paris Descartes University in Paris.

Research In 1994, she demonstrated the clinical impact of a new marker of cell proliferation, cyclin A, discovered in the same laboratory. In 1995, she was awarded the Prize of Scientific excellence Assistance Publique – Hôpitaux de Paris. Her work in Christian Brechot's team demonstrated the pro-carcinogenic impact of hepatitis B Virus (HBV) genome integration into cellular DNA both in patients having serological markers of HBV infection and in patients lacking serological markers but having persistence of the HBV DNA in their liver. The work of her team thus demonstrated a mechanism involved in the direct tumorigenic effect of this virus. In 2004 she was appointed full professor of cell biology in the same university. With her team, she published studies showing the primary role of calcium signalling deregulation in HBV and Hepatitis C virus (HCV) – related liver oncogenesis and in pathologies related to ER stress. From 2002 to 2006 she served as interim Director of INSERM Unit 370, previously directed by professor Christian Bréchot. In 2006, she was appointed Director of INSERM Unit 807. In addition to fundamental research studies, her activity has been focused to clinically applied research, targeting the domains of predictive oncology and non-invasive prenatal diagnosis.

The ISET technique

Source: The work of Patrizia Paterlini-Bréchot led to the discovery of the ISET test permitting the isolation and characterization of both circulating tumor and fetal cells. This discovery led Patrizia Paterlini-Bréchot to found her own company named Rarecells Diagnostics to develop the ISET technique.

Major publications P. Paterlini, M. Coppo, Metodologia diagnostica, Piccin Publishing, Padova, Italy, 1987.

Articles

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Worked examples

Example 1 — a first encounter with Patrizia Paterlini-Bréchot

Start with the simplest possible case. Write down what Patrizia Paterlini-Bréchot claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Patrizia Paterlini-Bréchot before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Patrizia Paterlini-Bréchot ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Patrizia Paterlini-Bréchot

In research: Patrizia Paterlini-Bréchot appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Patrizia Paterlini-Bréchot in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Patrizia Paterlini-Bréchot is common in secondary-school and first-year university syllabi. It links to neighbouring topics Inserm directors, Italian biologists, Italian women biologists, so understanding it makes those chapters shorter.
In everyday life: Look for Patrizia Paterlini-Bréchot outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Patrizia Paterlini-Bréchot in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Patrizia Paterlini-Bréchot means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Patrizia Paterlini-Bréchot out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Patrizia Paterlini-Bréchot in simple terms?

Why does Patrizia Paterlini-Bréchot matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Patrizia Paterlini-Bréchot?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Patrizia Paterlini-Bréchot.