astronomy

Paul Thomas Sharpe

Paul Thomas Sharpe is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Paul Thomas Sharpe rather than just read about it. In short: Paul Thomas Sharpe (born 12 December 1955) is a British biologist, currently serving as the Dickinson Professor of Craniofacial Biology and the Director of the Centre for Craniofacial and Regenerative Biology, King's College London. Education Sharpe was educated at De La Salle College, Sheffield (now All Saints Catholic High School, Sheffield) (1967–1974).

Key takeaways

Paul Thomas Sharpe belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Paul Thomas Sharpe to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Paul Thomas Sharpe from memory before moving on to harder problems.

Reference excerpt

Paul Thomas Sharpe (born 12 December 1955) is a British biologist, currently serving as the Dickinson Professor of Craniofacial Biology and the Director of the Centre for Craniofacial and Regenerative Biology, King's College London.

Education Sharpe was educated at De La Salle College, Sheffield (now All Saints Catholic High School, Sheffield) (1967–1974). He holds a BA in Biology from the University of York (1977) and a PhD from the University of Sheffield (1981).

Research Following his doctoral work at the University of Sheffield, Sharpe continued as a postdoctoral researcher there and also at the University of Wisconsin and the University of Cambridge prior to his first academic appointment at the University of Manchester (1997). Sharpe's research focuses on cell differentiation and began with his doctoral work on differentiation of the cellular slime mould Dictyostelium discoideum but he extended this work to mammalian tissues, principally bone. In this early work he applied the technique of thin layer countercurrent distribution. Subsequently, through the study of mouse embryo differentiation and the role of homeobox sequences in DNA, his work has mainly been applied to the field of craniofacial development. Most recently he has been leading research into the possibility of tooth regeneration and the development of new biological-based treatments for tooth repair. Sharpe is author of Methods of Cell Separation.

Awards and recognition Sharpe is an Honorary Fellow of the Royal College of Surgeons in Edinburgh (2010) and a recipient of the Gregor Mendel Memorial Medal (2003). He was awarded the Craniofacial Biology Research Award by the International Association for Dental Research (2004) and 2018 he received the William J Gies award for best publication is Biomaterials and Bioengineering (2018).

Personal life Sharpe (stage name Paul Shaft) is a musician and was a pioneer of the Sheffield punk music and new wave music scene. Originally he played bass guitar in the Sheffield band 2.3 and then formed the avant-garde band De Tian. He later played double bass and sang in the experimental jazz influenced band, Bass Tone Trap. Sharpe (Shaft) reformed 2.3 in 2018 and they have released two albums. Sharpe, a lifelong supporter of Sheffield United F.C. is married to Joy Elizabeth Sharpe (née Mitchell) and they have two children.

Bibliography Sharpe has over 300 publications listed on Web of Science which have been cited more than 14,500 times; his h-index is 66. His three most-cited articles are:

Theslef, I; Sharpe, P (1997). "Signalling networks regulating dental development". Mechanisms of Development. 67 (2): 111–123. doi:10.1016/s0925-4773(97)00115-9. PMID 9392510. S2CID 14900117. Qui, MS; Bulfone, A; Ghattas-Fernandez, I; Meneses, JJ; Christensen, L; Sharpe, PT; Presley, R; Pedersen, RA; Rubenstein, JLR (1997). "Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: Mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches". Developmental Biology. 185 (2): 165–184. doi:10.1006/dbio.1997.8556. PMID 9187081. Tucker, A; Sharpe, P (2004). "The cutting-edge of mammalian development; how the embryo makes teeth". Nature Reviews Genetics. 5 (7): 499–508. doi:10.1038/nrg1380. PMID 15211352. S2CID 42067451.

References

External links Official website Entry on Web of Science Entry on ORCID

Illustrations

Worked examples

Example 1 — a first encounter with Paul Thomas Sharpe

Start with the simplest possible case. Write down what Paul Thomas Sharpe claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Paul Thomas Sharpe before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Paul Thomas Sharpe ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Paul Thomas Sharpe

In research: Paul Thomas Sharpe appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Paul Thomas Sharpe in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Paul Thomas Sharpe is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1955 births, Alumni of the University of Sheffield, Alumni of the University of York, so understanding it makes those chapters shorter.
In everyday life: Look for Paul Thomas Sharpe outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Paul Thomas Sharpe in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Paul Thomas Sharpe means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Paul Thomas Sharpe out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Paul Thomas Sharpe in simple terms?

Why does Paul Thomas Sharpe matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Paul Thomas Sharpe?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Paul Thomas Sharpe.