Perazine (Taxilan) is a moderate-potency typical antipsychotic of the phenothiazine class. It is quite similar to chlorpromazine, and acts as a dopamine antagonist. It was very popular in West-Germany. A 2014 systematic review compared it with other antipsychotic drugs:
Synthesis
Phenothiazine-10-propionitrile [1698-80-2] (1) is treated with a mixture of acid and alcohol giving Methyl phenothiazinepropionate, CID:368244 (2). Heating with 1-methylpiperazine (3) gives the amide [91508-47-3] (4). Reduction of this last by means of diborane yields Perazine (5).
See also Carphenazine Dixyrazine Methdilazine Pipamazine
References
External links Perazine at the U.S. National Library of Medicine Medical Subject Headings (MeSH)


![Perazine: Perazine synthesis:[2][3] Patents:[4][5] Alternate source:[6][7]](https://upload.wikimedia.org/wikipedia/commons/thumb/5/5a/Perazine_synthesis.svg/500px-Perazine_synthesis.svg.png?utm_source=en.wikipedia.org&utm_campaign=parser&utm_content=thumbnail)
