Periglandula clandestina is a fungus of the genus Periglandula. It is symbiotic with the morning glory plant Ipomoea tricolor (the Mexican morning glory). Ipomoea tricolor seeds are hallucinogenic in humans due to the presence of naturally occurring lysergamides or ergot alkaloids like ergine (lysergic acid amide; LSA) and isoergine (isolysergic acid amide; iso-LSA). The lysergamides present in Ipomoea tricolor are produced by Periglandula clandestina that it is symbiotic with rather than by Ipomoea tricolor itself. Periglandula clandestina, isolated from Ipomoea tricolor, was discovered and first described by Corinne Hazel and Daniel Panaccione at West Virginia University in 2025. P. clandestina was quantified most abundantly in hypocotyls of I. tricolor, with lesser quantities in stems, cotyledons, and leaves. The fungus was not detected in roots, although ergot alkaloids were abundant in all tissues including roots. In each tissue, LAH was the most abundant alkaloid (77% of the measured ergot alkaloids), followed in abundance by ergine and ergonovine. Apart from roots, tissues that had relatively high fungal DNA values also had relatively high ergot alkaloid value
See also Periglandula ipomoeae Periglandula turbinae
References
Beaulieu, Wesley T.; Panaccione, Daniel G.; Quach, Quynh N.; Smoot, Katy L.; Clay, Keith (2021-12-06). "Diversification of ergot alkaloids and heritable fungal symbionts in morning glories". Communications Biology. 4 (1): 1362. doi:10.1038/s42003-021-02870-z. ISSN 2399-3642. PMC 8648897. PMID 34873267.
External links We Finally Found the Morning Glory Acid / Student Scientist Discovers Mysterious Fungus Behind LSD's Botanical Origins - Double Blind Magazine POD 128: Dr. Daniel Panaccione on a newly discovered lysergamide producing fungus - The Hamilton Morris Podcast
