Peter McGuffin (04 February 1949 – 30 January 2024) was a Northern Irish psychiatrist and geneticist from Belfast.
Early life Peter McGuffin was born in Belfast, Northern Ireland on 4 February 1949. He was the eldest of three children of Martha Melba (née Burnison) and William Brown McGuffin, a merchant navy officer and Royal Naval reservist. The family moved to the Isle of Wight in 1959 when William was appointed a Trinity House Pilot for the Port of Southampton.
Education and career summary McGuffin entered Isle of Wight's Sandown Grammar School at age 10. At age 15 he made an early career choice, deciding to become a psychiatrist after coming across Freud's Introductory Lectures on Psychoanalysis in the local public library at Ryde. He attended medical school at the University of Leeds, where he graduated in 1972 and then received postgraduate training in internal medicine. At this stage, he became interested in genetics and had his first publications on immunogenetic aspects of coronary heart disease. While he and his wife Anne Farmer were still junior doctors in Leeds, he transitioned this interest to psychiatric disorders and carried out one of the first genetic marker association studies on schizophrenia. This research suggested an association between the HLA system and the disorder, which was subsequently confirmed 36 years later by a genome-wide association study, led by one of McGuffin's former PhD students Michael C. O'Donovan. McGuffin completed his training as a psychiatrist at the Maudsley Hospital, London and was awarded a Medical Research Council Fellowship to study genetics at the University of London and at Washington University in St. Louis, where he spent a formative 18 months under the mentorship of 'Ted' Theodore Reich and Irving Gottesman. He completed a PhD with a thesis describing one of the first multi-marker genetic linkage studies in schizophrenia. He then became an MRC Senior Clinical Fellow at the Maudsley and the Institute of Psychiatry (now part of King's College London) and then took up the Chair of Psychological Medicine at the University of Wales College of Medicine in Cardiff in 1987. He subsequently established the Cardiff department as one of the World's leading centres for psychiatric genetic research, and was among the early pioneers of multi-centre international collaborations in psychiatric genetics such as the European Science Foundation programme on the Molecular Neurobiology of Mental Illness (MNMI). He moved back to London as successor to Prof Sir Michael Rutter as Director of the MRC Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry in October 1998. From January 2007 to December 2009, he was the Dean of the Institute of Psychiatry. He was elected a founder Fellow of the Academy of Medical Sciences in 1998. Despite his very early Freudian leanings, McGuffin's research and publications have mainly focused on the genetics of normal and abnormal behaviour.
Contributions to research
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