Phenol O-methyltransferase (EC 2.1.1.25) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which phenol is converted to anisole. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which loses its methyl group and becomes S-adenosyl-L-homocysteine (SAH). This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:phenol O-methyltransferase. It is also called PMT and can convert other substituted phenols to their corresponding methyl ethers.
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