Phenoxyethylamine, also known as 2-phenoxyethylamine, is a chemical compound related to phenethylamine (2-phenylethylamine). It is a parent compound of several psychedelic-related drugs including 3,4,5-trimethoxyphenoxyethylamine, CT-4719 (2,4-dichloro-5-methoxyphenoxyethylamine), CT-5126, and ORG-37684. It is also a parent compound of other drugs like the α-adrenergic receptor antagonist phenoxybenzamine, the α2-adrenergic receptor modulators lofexidine, allyphenyline, and cyclomethyline, the β-adrenergic receptor agonists dextrofemine and isoxsuprine, the beta blocker carvedilol, the antihistamine phenyltoloxamine, the sodium channel blocker mexiletine, and the coronary vasodilator fenalcomine, among others. There is a compound in the literature called 2,4-dichloro-6-phenoxyethyl-amine (aka DPEA or Lilly-32391 c.f. Lilly 18947). DPEA acts as a potent inhibitor of oxidative drug metabolism (e.g., microsomal demethylation and hydroxylation pathways) in a way similar to proadifen.
See also Propanolamines
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