biology

Philip Lazarovici

Philip Lazarovici is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Philip Lazarovici rather than just read about it. In short: Philip Lazarovici (Hebrew: פיליפ לזרוביץ) is a neuropharmacologist at the Hebrew University of Jerusalem and a member of the Institute of Drug Research of the School of Pharmacy. Education Philip was born to Bracha (Fishler) and Leon Lazarovici on 1 October 1949 in Roman, Romania to a Jewish family.

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Reference excerpt

Philip Lazarovici (Hebrew: פיליפ לזרוביץ) is a neuropharmacologist at the Hebrew University of Jerusalem and a member of the Institute of Drug Research of the School of Pharmacy.

Education Philip was born to Bracha (Fishler) and Leon Lazarovici on 1 October 1949 in Roman, Romania to a Jewish family. When he was 13 years old, his family immigrated to Israel where he developed an early interest in biology. He attended the Alliance Israélite Universelle-Carmia High School in Jerusalem and later, he enrolled in Israeli Defense Forces (IDF) Armored Infantry until 1971, serving as first sergeant. He completed his Bachelor of Science in biology, Master of Sciences in zoology, and Doctor of Philosophy (PhD) in toxicology, all from the Hebrew University of Jerusalem. He began his postdoctoral fellowship in Neurobiology at The Weizmann Institute of Science, Rehovot, Israel.

Research and career Lazarovici mainly researched on a variety of cellular and molecular aspects in the fields of neuroscience and cancer with a major emphasis on nerve growth factor (NGF) and toxins action, to dissect and characterize different biological aspects and to provide lead compounds for drug development. He along with his NIH colleagues, has contributed to the consensus-signaling map of NGF in neuronal differentiation, which has been recognized by the Signal Transduction Knowledge Environment (STKE). He developed and investigated different neuroprotective compounds and approaches towards neuronal ischemia in stroke, and traumatic brain injury. Lazarovici also contributed to the characterization of NGF angiogenic properties and characterization of human umbilical cord blood-derived stem cells. He is best known for his work on heterologous down-regulation of EGF receptor by NGF, which would appear to be an efficient mean of desensitizing the neurons to proliferative signals. Lazarovici pursued neuroscience as a visiting associate in the Section on Growth Factors at National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA. After completion of his research, he joined as lecturer in The School of Pharmacy, The Hebrew University of Jerusalem and later he became the full Professor. He is an active member of the Israel Societies for Physiology and Pharmacology (ISPP), and Neuroscience (ISN), American Societies for Neuroscience (ASN), and Pharmacology and Experimental Therapeutics (ASPET). Lazarovici was part of the Israeli group developing with TEVA Co. the drug for Parkinson's named Rasagiline (Azilect). Lazarovici is one of the highly cited author with a h-index of 49, he published around 235 scientific articles and edited six books in his field of research.

Patents Lazarovici, together with his collaborators, obtained many patents for his inventions. His patents include; "Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices"; "Near-infrared fluorescent particles and uses thereof"; "Soy-derived bioactive peptides for use in compositions and methods for wound healing, tissue engineering, and regenerative medicine"; and "Viperistatin-derived peptides and uses thereof".

Publications Vaudry, D.; Stork, PJ; Lazarovici, P; Eiden, LE (31 May 2002). "Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections". Science. 296 (5573): 1648–1649. Bibcode:2002Sci...296.1648V. doi:10.1126/science.1071552. PMID 12040181. S2CID 24865425. Tabakman, R.; Jiang, H; Shahar, I; Arien-Zakay, H; Levine, RA; Lazarovici, P (1 August 2005). "Neuroprotection by NGF in the PC12 In Vitro OGD Model: Involvement of Mitogen-Activated Protein Kinases and Gene Expression". Annals of the New York Academy of Sciences. 1053 (1): 84–96. Bibcode:2005NYASA1053...84T. doi:10.1196/annals.1344.008. PMID 16179511. Lahiani, Adi; Brand-Yavin, Annette; Yavin, Ephraim; Lazarovici, Philip (8 February 2018). "Neuroprotective Effects of Bioactive Compounds and MAPK Pathway Modulation in "Ischemia"—Stressed PC12 Pheochromocytoma Cells". Brain Sciences. 8 (2): 32. doi:10.3390/brainsci8020032. PMC 5836051. PMID 29419806. Gincberg, Galit; Shohami, Esther; Trembovler, Victoria; Alexandrovich, Alexander G.; Lazarovici, Philip; Elchalal, Uriel (February 2018). "Nerve growth factor plays a role in the neurotherapeutic effect of a CD45 + pan-hematopoietic subpopulation derived from human umbilical cord blood in a traumatic brain injury model". Cytotherapy. 20 (2): 245–261. doi:10.1016/j.jcyt.2017.11.008. PMID 29274773. Karatzas, Andreas; Katsanos, Konstantinos; Lilis, Ioannis; Papadaki, Helen; Kitrou, Panagiotis; Lecht, Shimon; Marcinkiewicz, Cezary; Siablis, Dimitris; Lelkes, Peter I.; Lazarovici, Philip; Tsopanoglou, Nikos E. (September 2013). "NGF Promotes Hemodynamic Recovery in a Rabbit Hindlimb Ischemic Model Through trkA- and VEGFR2-dependent Pathways". Journal of Cardiovascular Pharmacology. 62 (3): 270–277. doi:10.1097/FJC.0b013e3182982de7. PMID 23644989. S2CID 601556. Mirshahi, P; Rafii, A; Vincent, L; Berthaut, A; Varin, R; Kalantar, G; Marzac, C; Calandini, O A; Marie, J-P; Soria, C; Soria, J; Mirshahi, M (2 April 2009). "Vasculogenic mimicry of acute leukemic bone marrow stromal cells". Leukemia. 23 (6): 1039–1048. doi:10.1038/leu.2009.10. PMID 19340002. Cohen, Gadi; Ettinger, Keren; Lecht, Shimon; Lelkes, Peter I.; Lazarovici, Philip (31 July 2014). "Transcriptional Down-regulation of Epidermal Growth Factor (EGF) Receptors by Nerve Growth Factor (NGF) in PC12 Cells". Journal of Molecular Neuroscience. 54 (3): 574–585. doi:10.1007/s12031-014-0388-2. PMID 25078264. S2CID 1620005.

References

Worked examples

Example 1 — a first encounter with Philip Lazarovici

Start with the simplest possible case. Write down what Philip Lazarovici claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Philip Lazarovici before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Philip Lazarovici ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Philip Lazarovici

In research: Philip Lazarovici appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Philip Lazarovici in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Philip Lazarovici is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1949 births, Academic staff of the Hebrew University of Jerusalem, Israeli neuroscientists, so understanding it makes those chapters shorter.
In everyday life: Look for Philip Lazarovici outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Philip Lazarovici in 20 minutes

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Frequently asked questions

What is Philip Lazarovici in simple terms?

Philip Lazarovici (Hebrew: פיליפ לזרוביץ) is a neuropharmacologist at the Hebrew University of Jerusalem and a member of the Institute of Drug Research of the School of Pharmacy. Education Philip was born to Bracha (Fishler) and Leon Lazarovici on 1 October 1949 in Roman, Romania to a Jewish family.

Why does Philip Lazarovici matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Philip Lazarovici?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Philip Lazarovici.