Pholedrine, also known as 4-hydroxy-N-methylamphetamine and sold under the brand names Paredrinol, Pulsotyl, and Veritol among others, is a sympathomimetic drug used in topical eye drops to dilate the pupil. It can be used to diagnose Horner's syndrome. In 2004, it remained marketed only in Germany.
Pharmacology
Pharmacodynamics Pholedrine is described as a sympathomimetic, antihypotensive, and ephedrine-like agent.
Chemistry Pholedrine, also known as 4-hydroxy-N-methylamphetamine, is a substituted phenethylamine and amphetamine derivative. It is structurally related to methamphetamine (N-methylamphetamine), norpholedrine (4-hydroxyamphetamine), oxilofrine (4,β-dihydroxy-N-methylamphetamine), and tyramine (4-hydroxyphenethylamine). It is used pharmaceutically as the sulfate salt. The predicted log P of pholedrine ranges from 1.12 to 1.7.
History Pholedrine was synthesized by 1951.
Society and culture
Names Pholedrine is the generic name of the drug and its INNTooltip International Nonproprietary Name, BANTooltip British Approved Name, and DCFTooltip Dénomination Commune Française, while foledrina is its DCITTooltip Denominazione Comune Italiana. The drug has been sold under brand names including Pholedrin Liquidum, Pholedrin-Longo-Isis, Presoitan, Veritain, and Veritol among others.
Other drugs Pholedrine (4-hydroxymethamphetamine) is also a major metabolite of methamphetamine.
References