Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa. Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.
Interactions Noxa has been shown to interact with:
BCL2-like 1, Bcl-2, and MCL1.
See also Apoptosis Apoptosome Bcl-2 Bcl-2-associated X protein (BAX) BH3 interacting domain death agonist (BID) Caspases Cytochrome c Mitochondrion p53 upregulated modulator of apoptosis (PUMA) 12-O-Tetradecanoylphorbol-13-acetate (Phorbol-12-myristate-13-acetate)
References
Further reading
External links NOXA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)