Phosphatidylserine decarboxylase is an enzyme that in humans is encoded by the PISD gene.
Function Phosphatidylserine decarboxylase (EC 4.1.1.65) catalyzes the chemical reaction
phosphatidyl-L-serine ⇌ {\displaystyle \rightleftharpoons } phosphatidylethanolamine + CO2 This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming). Other names in common use include PS decarboxylase, and phosphatidyl-L-serine carboxy-lyase. This enzyme participates in glycine, serine and threonine metabolism, and glycerophospholipid metabolism. It has two cofactors: pyridoxal phosphate, and Pyruvate.
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