In enzymology, a phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) is an enzyme that catalyzes the chemical reaction
phosphoenolpyruvate + protein histidine ⇌ {\displaystyle \rightleftharpoons } pyruvate + protein Npi-phospho-L-histidine Thus, the two substrates of this enzyme are phosphoenolpyruvate and protein histidine, whereas its two products are pyruvate and protein Npi-phospho-L-histidine. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. This enzyme participates in phosphotransferase system (pts).
Nomenclature The systematic name of this enzyme class is phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase. Other names in common use include phosphoenolpyruvate sugar phosphotransferase enzyme I, phosphopyruvate-protein factor phosphotransferase, phosphopyruvate-protein phosphotransferase, sugar-PEP phosphotransferase enzyme I, and phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase.
References
Postma PW, Roseman S (December 1976). "The bacterial phosphoenolpyruvate: sugar phosphotransferase system". Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes. 457 (3–4): 213–57. doi:10.1016/0304-4157(76)90001-0. PMID 187249.
