Phosphoramides are a class of phosphorus compounds with the formula O=P(NR2)3-nRn (R = anything). They can be considered derivatives of phosphoric acid where OH groups have been replaced with an amino or R-substituted amino group. In practise the term is commonly confined to the phosphoric triamides (P(=O)(NR2)3), essentially phosphoramide and derivatives thereof. Derivatives with the general structures P(=O)(OH)(NR2)2 or P(=O)(OH)2(NR2) are usually referred to as phosphoramidic acids.
Examples Na[PO2(OH)(NH2)], the lightly studied parent monoamide of phosphoric acid. Phenyl phosphorodiamidate, a phosphoramide but also a phosphate ester, is used in agriculture to enhance the effectiveness of urea-based fertilizers. Hexamethylphosphoramide (HMPA) is a polar solvent. Cyclophosphamide, Chlorambucil, Ifosfamide, and Trofosfamide are phosphoramide-containing anticancer drugs
References


