The enzyme phosphoserine phosphatase (EC 3.1.3.3) catalyzes the reversible reaction
O-phospho-L(or D)-serine + H2O ⇌ {\displaystyle \rightleftharpoons } L(or D)-serine + phosphate For example, with L-phosphoserine as substrate the hydrolysis reaction gives L-serine, with orthophosphate as byproduct:
The enzyme was characterised from chicken and rat liver. It is also present in humans, where it regulates glycine and D-serine levels. The reaction is the final, irreversible, step in L-serine biosynthesis. The enzyme is classified as a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is O-phosphoserine phosphohydrolase.
Structural studies As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1F5S, PDB: 1J97, PDB: 1L7M, PDB: 1L7N, PDB: 1L7O, PDB: 1L7P, PDB: 1L8L, PDB: 1L8O, PDB: 1NNL, PDB: 2J6Y, PDB: 2J6Z, and PDB: 2J70.
References



