science

Polyphenon

Polyphenon is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Polyphenon rather than just read about it. In short: Polyphenon is a series of high grade green tea polyphenol extracts manufactured by the Mitsui Norin Co., Ltd. of Japan. The extracts are in part the result of a water based extraction method which begins with green tea leaves, and then involves successive steps which concentrate the catechins thought to be responsible for the health benefits of green tea.

Key takeaways

Polyphenon belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Polyphenon to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Polyphenon from memory before moving on to harder problems.

Reference excerpt

Polyphenon is a series of high grade green tea polyphenol extracts manufactured by the Mitsui Norin Co., Ltd. of Japan. The extracts are in part the result of a water based extraction method which begins with green tea leaves, and then involves successive steps which concentrate the catechins thought to be responsible for the health benefits of green tea. As of October 2016, 20 clinical trials have been published for Polyphenon E (16 oral and 4 topical). In 2006 the U.S. Food and Drug Administration approved as a drug an ointment containing 15% Polyphenon E for the treatment of genital and perianal warts. The product name is Veregen. To date, no oral use of the product has been approved. Many dietary supplement companies sell green tea extracts as supplements, but as such, are not allowed to make any disease treatment or prevention claims.

Clinical trials 1. Joe AK, Schnoll-Sussman F, et al. Phase Ib randomized, double-blinded, placebo-controlled, dose escalation study of Polyphenon E in patients with Barrett's Esophagus. Cancer Prev Res (Phila). 2015;8:1131-7. 2. Lovera J, Ramos A, et al. Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies. J Neurol Sci. 2015;358(1-2):46-52. 3. Kumar NB, Pow-Sang J, et al. Randomized, placebo-controlled trial of green tea catechins for prostate cancer prevention. Cancer Prev Res (Phila). 2015;8(10):879-87. 4. Crew KD, Ho KA, et al. Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signaling in women with hormone receptor-negative breast cancer. J Hum Nutr Diet. 2015;28(3):272-82. 5. Garcia FA, Cornelison T, et al. Results of a phase II randomized, double-blind, placebo-controlled trial of Polyphenon E in women with persistent high-risk HPV infection and low-grade cervical intraepithelial neoplasia. Gynecol Oncol. 2014;132(2):377-82. 6. Dryden GW, Lam A, Beatty K, Qazzaz HH, McClain CJ. A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis. Inflamm Bowel Dis. 2013;19(9):1904-12. 7. Crew KD, Brown P, et al. Phase IB randomized, double-blinded, placebo-controlled, dose escalation study of polyphenon E in women with hormone receptor-negative breast cancer. Cancer Prev Res (Phila). 2012;5(9):1144-54. 8. Shanafelt TD, Call TG, et al. Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer. 2013;119(2):363-70. 9. Wu AH, Spicer D, Stanczyk FZ, Tseng CC, Yang CS, Pike MC. Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women. Cancer Prev Res (Phila). 2012;5(3):393-402. 10. Nguyen MM, Ahmann FR, et al. Randomized, double-blind, placebo-controlled trial of polyphenon E in prostate cancer patients before prostatectomy: evaluation of potential chemopreventive activities. Cancer Prev Res (Phila). 2012;5(2):290-8. 11. McLarty J, Bigelow RL, et al. Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro. Cancer Prev Res (Phila). 2009;2(7):673-82. 12. Shanafelt TD, Call TG, et al. Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia. J Clin Oncol. 2009;27:3808-14. 13. Auger C, Mullen W, Hara Y, Crozier A. Bioavailability of polyphenon E flavan-3-ols in humans with an ileostomy. J Nutr. 2008;138(8):1535S-1542S. 14. Chow HH, Hakim IA, et al. Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. Clin Cancer Res. 2005;11(12):4627-33. 15. Chow HH, Cai Y, et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res. 2003;9(9):3312-9. 16. Chow HH, Cai Y, et al. Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. Cancer Epidemiol Biomarkers Prev. 2001;10(1):53-8. 17. Tatti S, Stockfleth E, et al. Polyphenon E: a new treatment for external anogenital warts. Br J Dermatol. 2010;162(1):176-84. 18. Stockfleth E, Beti H, Orasan R, Grigorian F, Mescheder A, Tawfik H, Thielert C. Topical Polyphenon E in the treatment of external genital and perianal warts: a randomized controlled trial. Br J Dermatol. 2008 Jun;158(6):1329-38. 19. Gross G, Meyer KG, Pres H, Thielert C, Tawfik H, Mescheder A. A randomized, double-blind, four-arm parallel-group, placebo-controlled Phase II/III study to investigate the clinical efficacy of two galenic formulations of Polyphenon E in the treatment of external genital warts. J Eur Acad Dermatol Venereol. 2007 Nov;21(10):1404-12. 20. Ahn WS, Yoo J, Huh SW, Kim CK, Lee JM, Namkoong SE, Bae SM, Lee IP. Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions. Eur J Cancer Prev. 2003 Oct;12(5):383-90.

References

External links Polyphenon Mitsui Norin Co Ltd

Worked examples

Example 1 — a first encounter with Polyphenon

Start with the simplest possible case. Write down what Polyphenon claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Polyphenon before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Polyphenon ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Polyphenon

In research: Polyphenon appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Polyphenon in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Polyphenon is common in secondary-school and first-year university syllabi. It links to neighbouring topics Dietary antioxidants, Tea, so understanding it makes those chapters shorter.
In everyday life: Look for Polyphenon outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “Polyphenon” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Polyphenon in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Polyphenon means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Polyphenon out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Polyphenon in simple terms?

Why does Polyphenon matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Polyphenon?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Polyphenon.