chemistry

Povl Krogsgaard-Larsen

Povl Krogsgaard-Larsen is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Povl Krogsgaard-Larsen rather than just read about it. In short: Povl Krogsgaard-Larsen (born May 17, 1941) is a Danish medicinal chemist who studies the glutamatergic, GABAergic, and cholinergic neurotransmitter systems and drugs acting on these systems. He is known for discovering and developing the AMPA receptor agonist AMPA and the Amanita muscaria- or muscimol-derived GABAA receptor agonist THIP (gaboxadol), among many other scientific contributions.

Key takeaways

Povl Krogsgaard-Larsen belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Povl Krogsgaard-Larsen to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Povl Krogsgaard-Larsen from memory before moving on to harder problems.

Reference excerpt

Povl Krogsgaard-Larsen (born May 17, 1941) is a Danish medicinal chemist who studies the glutamatergic, GABAergic, and cholinergic neurotransmitter systems and drugs acting on these systems. He is known for discovering and developing the AMPA receptor agonist AMPA and the Amanita muscaria- or muscimol-derived GABAA receptor agonist THIP (gaboxadol), among many other scientific contributions. Some other notable drugs he has developed include the GABAA receptor agonist isoguvacine and the GABA reuptake inhibitors nipecotic acid and guvacine (which led to the subsequent independent development of tiagabine). Krogsgaard-Larsen has published more than 400 scientific papers and has edited 8 books. He is considered to be a giant in the field of medicinal chemistry and to be the most impactful Danish medicinal chemist. An autobiography was published for Krogsgaard-Larsen in 2011.

Selected publications Krogsgaard-Larsen P, Johnston GA (December 1975). "Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds". J Neurochem. 25 (6): 797–802. doi:10.1111/j.1471-4159.1975.tb04410.x. PMID 1206398. Krogsgaard-Larsen P, Johnston GA, Curtis DR, Game CJ, McCulloch RM (December 1975). "Structure and biological activity of a series of conformationally restricted analogues of GABA". J Neurochem. 25 (6): 803–809. doi:10.1111/j.1471-4159.1975.tb04411.x. PMID 1206399. Krogsgaard-Larsen P, Johnston GA, Lodge D, Curtis DR (July 1977). "A new class of GABA agonist". Nature. 268 (5615): 53–55. doi:10.1038/268053a0. PMID 196200. Krogsgaard-Larsen P, Honoré T, Hansen JJ, Curtis DR, Lodge D (March 1980). "New class of glutamate agonist structurally related to ibotenic acid". Nature. 284 (5751): 64–66. doi:10.1038/284064a0. PMID 6101908. Honoré T, Lauridsen J, Krogsgaard-Larsen P (January 1982). "The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes". J Neurochem. 38 (1): 173–178. doi:10.1111/j.1471-4159.1982.tb10868.x. PMID 6125564. Bräuner-Osborne H, Egebjerg J, Nielsen EO, Madsen U, Krogsgaard-Larsen P (July 2000). "Ligands for glutamate receptors: design and therapeutic prospects". J Med Chem. 43 (14): 2609–2645. doi:10.1021/jm000007r. PMID 10893301. Jensen AA, Frølund B, Liljefors T, Krogsgaard-Larsen P (July 2005). "Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations". J Med Chem. 48 (15): 4705–4745. doi:10.1021/jm040219e. PMID 16033252. Demmer CS, Krogsgaard-Larsen N, Bunch L (December 2011). "Review on modern advances of chemical methods for the introduction of a phosphonic acid group". Chem Rev. 111 (12): 7981–8006. doi:10.1021/cr2002646. PMID 22010799. Stromgaard, K.; Krogsgaard-Larsen, P.; Madsen, U. (2022). Textbook of Drug Design and Discovery (5 ed.). Taylor & Francis Limited (Sales). ISBN 978-1-032-33994-8. Retrieved 10 February 2025.

References

Worked examples

Example 1 — a first encounter with Povl Krogsgaard-Larsen

Start with the simplest possible case. Write down what Povl Krogsgaard-Larsen claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Povl Krogsgaard-Larsen before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Povl Krogsgaard-Larsen ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Povl Krogsgaard-Larsen

In research: Povl Krogsgaard-Larsen appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Povl Krogsgaard-Larsen in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Povl Krogsgaard-Larsen is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1941 births, Academic staff of the University of Copenhagen, Danish chemists, so understanding it makes those chapters shorter.
In everyday life: Look for Povl Krogsgaard-Larsen outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “Povl Krogsgaard-Larsen” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Povl Krogsgaard-Larsen in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Povl Krogsgaard-Larsen means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Povl Krogsgaard-Larsen out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Povl Krogsgaard-Larsen in simple terms?

Why does Povl Krogsgaard-Larsen matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Povl Krogsgaard-Larsen?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Povl Krogsgaard-Larsen.