Precorrin-4 C11-methyltransferase (EC 2.1.1.133) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the cobalamin precursor, precorrin-4, is converted to precorrin-4. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Pseudomonas denitrificans and Salmonella typhimurium. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase. Other names in common use include precorrin-3 methylase, and CobM. It is part of the biosynthetic pathway to vitamin B12 in aerobic bacteria.
See also Cobalamin biosynthesis
Structural studies As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 1CBF and PDB: 2CBF.
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