chemistry

Preladenant

Preladenant is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Preladenant rather than just read about it. In short: Preladenant (developmental code name SCH-420814) is a drug that was developed by Schering-Plough which acts as a potent and selective antagonist of the adenosine A2A receptor. It was being researched as a potential treatment for Parkinson's disease.

Key takeaways

Preladenant belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Preladenant to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Preladenant from memory before moving on to harder problems.

Reference excerpt

Preladenant (developmental code name SCH-420814) is a drug that was developed by Schering-Plough which acts as a potent and selective antagonist of the adenosine A2A receptor. It was being researched as a potential treatment for Parkinson's disease. Positive results were reported in Phase II clinical trials in humans, but it did not prove itself to be more effective than a placebo during Phase III trials, and so was discontinued in May 2013. The drug has very high affinity for the A2A receptor (<1 nM) and shows more than 1,000-fold selectivity for the A2A receptor over the other adenosine receptors. Preladenant shows pro-motivational effects in animals and reverses tetrabenazine-induced motivational deficits. Other A2A receptor antagonists, including istradefylline, Lu AA47070, MSX-3, and MSX-4, have also shown such effects. These agents may be useful in the treatment of motivational disorders in humans. Accordingly, istradefylline has been reported to reduce apathy, anhedonia, fatigue, and depression in people with Parkinson's disease.

See also List of investigational Parkinson's disease drugs

References

Illustrations

Worked examples

Example 1 — a first encounter with Preladenant

Start with the simplest possible case. Write down what Preladenant claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Preladenant before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Preladenant ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Preladenant

In research: Preladenant appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Preladenant in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Preladenant is common in secondary-school and first-year university syllabi. It links to neighbouring topics 2-Furyl compounds, Abandoned drugs, Adenosine receptor antagonists, so understanding it makes those chapters shorter.
In everyday life: Look for Preladenant outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Preladenant in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Preladenant means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Preladenant out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Preladenant in simple terms?

Why does Preladenant matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Preladenant?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Preladenant.