Prenatal stress, also known as prenatal maternal stress, occurs when an expectant mother is exposed to psychosocial or physical stress. This can be brought on by daily events or environmental hardships.[1] [2] According to the Developmental Origins of Health and Disease (DOHaD), a wide range of environmental factors a woman may experience during the perinatal period can contribute to biological impacts and changes in the fetus that then cause health risks later in the child's life. Health risks include impaired cognitive development, low birth weight, mental disorders, and gender specific deficits in the offspring.
Research
Studies explore the way that prenatal stress impacts the fetus's development. One of the ways the body responds to stress is via the hypothalamic-pituitary-adrenal (HPA) axis. Expectant mothers that experience high levels of stressors trigger a response from the HPA axis. This then triggers the release of glucocorticoids. This increases the level of glucocorticoid in the mother and the fetus. Studies show that elevated levels of glucocorticoids can affect neurodevelopment in the fetus. Some research includes studies like McKenna et al. suggesting that the idea of pregnancy can cause an increased risk of psychopathology and these exposures during gestation impacts epigenetic. The mother's usage of selective serotonin repute inhibitors (SSRIs) was observed while the epigenetic age of the child was calculated through fetal umbilical cord blood. Saboory et al. found that prenatal psychosocial stress can cause delays in child growth and development through assessing the child's weight, height and head circumference every two months after they were born. They also assessed the child's cognitive development through the use of the Ages and Stages Questionnaire (ASQ). Another study, Brannigan et al. focused on how prenatal stress contributes to personality disorders by looking at children decades later born from mothers who spent time in a mental health clinic in Finland. All of this research had found negative correlations between prenatal stress and the child's development.
Timing of prenatal stress A study by Sandman and Davis shows that the timing of prenatal stress is crucial to understanding how prenatal stress affects prenatal and postnatal development. Cortisol is often used to measure stress as it is a hormone that is released during stressful events. If an expectant mother is experiencing a stressful event such as income insecurity or being a teenage mother, cortisol is secreted as a result. However, as demonstrated by Sandman and Davis, the timing of cortisol release can sometimes have a harmful effect on development and sometimes not depending on when in pregnancy stress is experienced. Prenatal stress can increase the likelihood of maternal and endocrinological problems. Prenatal stress can even cause the embryo to arrive earlier than expected. Sandman and Davis studied "125 full- term infants at 3, 6, and 12 months of age" to determine the effects of maternal cortisol timing differences on development. They found that "exposure to elevated concentrations of cortisol early in gestation was associated with a slower rate of development over the 1st year and lower mental development scores at 12 months" and "elevated levels of maternal cortisol late in gestation were associated with accelerated cognitive development and higher scores at 12 months". Overall, cortisol's effects on infant cognitive development are dependent upon the timing of cortisol release. Furthermore, prenatal stress can have an effect on fetal development by causing obesity, diabetes, cardiovascular disease, and other problems.
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