In enzymology, a protein-serine epimerase (EC 5.1.1.16) is an enzyme that catalyzes the chemical reaction
[protein]-L-serine ⇌ {\displaystyle \rightleftharpoons } [protein]-D-serine Hence, this enzyme has one substrate, [protein]-L-serine, and one product, [protein]-D-serine. This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is [protein]-serine epimerase. This enzyme is also called protein-serine racemase.
Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1WTC.
References
Katayama K, Kuwada M (1995). "Isolation and characterization of a peptide isomerase from funnel web spider venom". J. Biol. Chem. 270 (28): 16719–23. doi:10.1074/jbc.270.28.16719. PMID 7622482.
