Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.
Function Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.
Interactions CBY1 has been shown to interact with Beta-catenin. CBY1 has also been shown to interact with CEP164, CIBAR1 (FAM92A1), and RAB8A.
References
External links Human CBY1 genome location and CBY1 gene details page in the UCSC Genome Browser.
Further reading






