Pyomyositis (Myositis tropicans) is a bacterial infection of the skeletal muscles which results in an abscess. Pyomyositis is most common in tropical areas but can also occur in temperate zones. Pyomyositis can be classified as primary or secondary. Primary pyomyositis is a skeletal muscle infection arising from hematogenous infection, whereas secondary pyomyositis arises from localized penetrating trauma or contiguous spread to the muscle.
Diagnosis Diagnosis is done via the following manner:
Pus discharge culture and sensitivity X ray of the part to rule out osteomyelitis Creatinine phosphokinase (more than 50,000 units) MRI is useful Ultrasound guided aspiration Bioptates of affected muscle tissues show acute and chronic inflammatory cells, and in one case caused by influenza A infection muscle cells show lack of nuclei.
Symptoms Pyogenic symptoms usually are present in the following muscles:
serratus anterior pectoralis major biceps abdominal muscles spinal muscles glutei iliopsoas quadriceps gastrocnemicus The course of this disease is divided into three distinct phases. The invasive stage manifests as general muscle soreness and swelling without erythema and low-grade fever and lasts about ten days. The purulent-suppurative stage occurs after about 2–3 weeks and is associated with increased body temperature and muscle tenderness. In the third stage, sepsis occurs that can lead to serious complications, including death.
Treatment The abscesses within the muscle must be drained surgically (not all patients require surgery if there is no abscess). Antibiotics, such as vancomycin, teicoplanin, tigecycline, daptomycin or linezolid are given for a minimum of three weeks to clear the infection. In some cases, co-trimoxazole is sufficient.
Epidemiology Pyomyositis is most often caused by the bacterium Staphylococcus aureus. The infection can affect any skeletal muscle, but most often infects the large muscle groups such as the quadriceps or gluteal muscles. Pyomyositis is mainly a disease of children and was first described by Scriba in 1885. Most patients are aged 2 to 5 years, but infection may occur in any age group. Infection often follows minor trauma and is more common in the tropics, where it accounts for 4% of all hospital admissions. In temperate countries such as the US, pyomyositis was a rare condition (accounting for 1 in 3000 pediatric admissions), but has become more common since the appearance of the USA300 strain of MRSA. Pyomyositis is inherently related to residency in tropical areas, especially in northern Uganda, where yearly about 400-900 cases are reported. In these regions, the general population affected by this disease is not affected by other concommitant diseases. However, in temperate regions pyomyositis is usually present in immunocompromised individuals or people affected by chronic renal failure or rheumatoid arthritis. Gonococcal pyomyositis is a rare infection caused by Neisseria gonorrhoeae.
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References
Maravelas R, Melgar TA, Vos D, Lima N, Sadarangani S (2020). "Pyomyositis in the United States 2002-2014". J Infect. 80: 497–503. doi:10.1016/j.jinf.2020.02.005. PMID 32147332.{{cite journal}}: CS1 maint: multiple names: authors list (link).
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