chemistry

R-102444

R-102444 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand R-102444 rather than just read about it. In short: R-102444 is a serotonin 5-HT2 receptor antagonist which was under development for the treatment of peripheral arterial occlusive disorders and pancreatitis. It is a laurate (dodecanoate) ester prodrug of R-96544.

Key takeaways

R-102444 belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect R-102444 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of R-102444 from memory before moving on to harder problems.

Reference excerpt

R-102444 is a serotonin 5-HT2 receptor antagonist which was under development for the treatment of peripheral arterial occlusive disorders and pancreatitis. It is a laurate (dodecanoate) ester prodrug of R-96544. The drug has been found to inhibit serotonin-induced platelet aggregation and to have antithrombotic effects in preclinical research. The active form, R-96544, shows selectivity for the serotonin 5-HT2A receptor over other targets, including the serotonin 5-HT1, 5-HT2B, and 5-HT3 receptors as well as the dopamine D2 receptor and adrenergic receptors, among others. However, it also showed high affinity for the serotonin 5-HT2C receptor, which was about 4-fold less than for the serotonin 5-HT2A receptor. R-102444 was developed by Daiichi Sankyo Company. It reached the preclinical research stage of development prior to its discontinuation. R-102444 was first described in the scientific literature by Naoki Tanaka and colleagues by 2000.

See also Serotonin 5-HT2A receptor antagonist R-96544 Sarpogrelate

References

Illustrations

Worked examples

Example 1 — a first encounter with R-102444

Start with the simplest possible case. Write down what R-102444 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to R-102444 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about R-102444 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of R-102444

In research: R-102444 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses R-102444 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: R-102444 is common in secondary-school and first-year university syllabi. It links to neighbouring topics 5-HT2A antagonists, Abandoned drugs, Antiplatelet drugs, so understanding it makes those chapters shorter.
In everyday life: Look for R-102444 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study R-102444 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what R-102444 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain R-102444 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is R-102444 in simple terms?

Why does R-102444 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study R-102444?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on R-102444.