biology

RAD23A

RAD23A is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand RAD23A rather than just read about it. In short: UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene. Function The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER).

Key takeaways

RAD23A belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect RAD23A to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of RAD23A from memory before moving on to harder problems.

Reference excerpt

UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.

Function The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. RAD23A interacts with Y-family DNA polymerase iota (ι), DNA polymerase eta (η), DNA polymerase kappa and Y family DNA polymerase REV1. These polymerases have roles in the DNA damage tolerance pathway of translesion synthesis that allows the replication fork to continue without stalling even when damage is present.

Interactions RAD23A has been shown to interact with:

Ataxin 3, PSMD4, and Sequestosome 1.

References

Illustrations

Worked examples

Example 1 — a first encounter with RAD23A

Start with the simplest possible case. Write down what RAD23A claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to RAD23A before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about RAD23A ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of RAD23A

In research: RAD23A appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses RAD23A in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: RAD23A is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 19, Human chromosome 19 gene stubs, Human proteins, so understanding it makes those chapters shorter.
In everyday life: Look for RAD23A outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study RAD23A in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what RAD23A means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain RAD23A out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is RAD23A in simple terms?

UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene. Function The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER).

Why does RAD23A matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study RAD23A?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on RAD23A.