chemistry

RGFP136

RGFP136 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand RGFP136 rather than just read about it. In short: RGFP136, or RGFP-136, is a histone deacetylase (HDAC) inhibitor which is used in scientific research. It is a modestly selective or preferential HDAC3 inhibitor, with an IC50Tooltip half-maximal inhibitory concentration value of 400–560 nM, whereas the drug showed 2- to 13-fold lower inhibitory potency at HDAC1 and HDAC2 (IC50 = 1,140–5,200 nM and 3,000 nM, respectively).

Key takeaways

RGFP136 belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect RGFP136 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of RGFP136 from memory before moving on to harder problems.

Reference excerpt

RGFP136, or RGFP-136, is a histone deacetylase (HDAC) inhibitor which is used in scientific research. It is a modestly selective or preferential HDAC3 inhibitor, with an IC50Tooltip half-maximal inhibitory concentration value of 400–560 nM, whereas the drug showed 2- to 13-fold lower inhibitory potency at HDAC1 and HDAC2 (IC50 = 1,140–5,200 nM and 3,000 nM, respectively). It shows weak inhibition of HDAC8 and no inhibition of several other HDACs, including HDAC4, HDAC5, HDAC6, and HDAC7. RGFP136 has been found to enhance long-term memory in rodents, which led to conclusions that HDAC3 is a critical regulator of long-term memory formation. It has also been found to improve symptoms in an animal model of Friedreich ataxia. The drug's pharmacokinetics have been studied and it is brain-penetrant in rodents. RGFP136 was first described in the scientific literature by 2011.

See also Histone deacetylase inhibitor RGFP963 RGFP966

References

Worked examples

Example 1 — a first encounter with RGFP136

Start with the simplest possible case. Write down what RGFP136 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to RGFP136 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about RGFP136 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of RGFP136

In research: RGFP136 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses RGFP136 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: RGFP136 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Amines, Anilines, Benzamides, so understanding it makes those chapters shorter.
In everyday life: Look for RGFP136 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study RGFP136 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what RGFP136 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain RGFP136 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is RGFP136 in simple terms?

Why does RGFP136 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study RGFP136?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on RGFP136.