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chemistry

RGFP963

RGFP963 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand RGFP963 rather than just read about it. In short: RGFP963, or RGFP-963, is a histone deacetylase (HDAC) inhibitor which is used in scientific research. It is a selective class I HDAC inhibitor, including of HDAC1, HDAC2, and HDAC3 (IC50Tooltip half-maximal inhibitory concentration = 1,510 nM, 750 nM, and 96 nM, respectively).

RGFP963 — main illustration
RGFP963 — illustration

Key takeaways

  • RGFP963 belongs to chemistry; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect RGFP963 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of RGFP963 from memory before moving on to harder problems.

Reference excerpt

RGFP963, or RGFP-963, is a histone deacetylase (HDAC) inhibitor which is used in scientific research. It is a selective class I HDAC inhibitor, including of HDAC1, HDAC2, and HDAC3 (IC50Tooltip half-maximal inhibitory concentration = 1,510 nM, 750 nM, and 96 nM, respectively). The drug also weakly inhibits HDAC10 (IC50 = 6,640–10,000 nM), whereas it showed no inhibition of other HDACs at a concentration of up to 20,000 nM. RGFP963 enhances the consolidation of cued fear extinction in rodents, with this thought to be mediated by inhibition of HDAC1 and/or HDAC2 and not by inhibition of HDAC3. In addition, the drug promotes synaptogenesis in vitro and enhances memory in an animal model of Alzheimer's disease in rodents. It also enhanced cognition in a model of amyotrophic lateral sclerosis (ALS) in rodents. The pharmacokinetics of RGFP963 have been studied and it is brain-penetrant in rodents. RGFP963 was first described in the scientific literature by 2015.

See also Histone deacetylase inhibitor RGFP136 RGFP966

References

Illustrations

RGFP963 illustration

Worked examples

Example 1 — a first encounter with RGFP963

Start with the simplest possible case. Write down what RGFP963 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to RGFP963 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about RGFP963 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of RGFP963

In research
RGFP963 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses RGFP963 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
RGFP963 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Amides, Amines, Drugs not assigned an ATC code, so understanding it makes those chapters shorter.
In everyday life
Look for RGFP963 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study RGFP963 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what RGFP963 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain RGFP963 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is RGFP963 in simple terms?

RGFP963, or RGFP-963, is a histone deacetylase (HDAC) inhibitor which is used in scientific research. It is a selective class I HDAC inhibitor, including of HDAC1, HDAC2, and HDAC3 (IC50Tooltip half-maximal inhibitory concentration = 1,510 nM, 750 nM, and 96 nM, respectively).

Why does RGFP963 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study RGFP963?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on RGFP963.

Tags

  • Amides
  • Amines
  • Drugs not assigned an ATC code
  • Fear memory modulators
  • Histone deacetylase inhibitors
  • Nootropics
  • Phenyl compounds
  • Propyl compounds
  • Pyrazoles

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