astronomy

Rama Khokha

Rama Khokha is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Rama Khokha rather than just read about it. In short: Rama Khokha is a researcher and scientist in the field of medical biophysics and oncology. As of 2025, she serves as a senior scientist at the Princess Margaret Cancer Centre within the University Health Network and is a professor in the Department of Medical Biophysics, with a cross-appointment in the Department of Laboratory Medicine and Pathobiology at the University of Toronto.

Key takeaways

Rama Khokha belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Rama Khokha to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Rama Khokha from memory before moving on to harder problems.

Reference excerpt

Rama Khokha is a researcher and scientist in the field of medical biophysics and oncology. As of 2025, she serves as a senior scientist at the Princess Margaret Cancer Centre within the University Health Network and is a professor in the Department of Medical Biophysics, with a cross-appointment in the Department of Laboratory Medicine and Pathobiology at the University of Toronto.

Early life and education Khokha was born and raised in India. She received her M.Sc. from the University of Delhi, India and later received her Ph.D. in biochemistry in 1985 from the University of Western Ontario. Her postdoctoral work was done at the Cancer Research Labs in London, Ontario, until 1989. She received a Von Humboldt fellowship and spent two years at the European Molecular Biology Labs from 1990 to 1992. Khokha initiated her independent research program in 1990 at the London Regional Cancer Centre before joining the Ontario Cancer Institute at Princess Margaret Cancer Centre in 1996.

Research Khokha is known for her research on the understanding of cancers of the breast, liver, lung and bone, with a particular focus on understanding the molecular basis of breast cancer. She studies the tumor microenvironment and adult stem cell niches. She successfully mapped the biology of pancreatic cancer tumors and identifying three distinct tumor microenvironments. Her research uncovered insights into the role of progesterone in breast cancer stem cells and highlighted the importance of the TIMP gene family in regulating the tumor microenvironment. A research team led by Khokha found that aging can be prevented if the two factors that control tissue development are removed. When TIMP1 and TIMP3 were removed from mice, their breast tissue remained youthful.

Selected publications Khokha, Rama; Waterhouse, Paul; Yagel, Simcha; Lala, Peeyush K.; Overall, Christopher M.; Norton, Gill; Denhardt, David T. (1989-02-17). "Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells". Science. 243 (4893): 947–950. doi:10.1126/science.2465572. ISSN 0036-8075. Joshi, Purna A.; Jackson, Hartland W.; Beristain, Alexander G.; Di Grappa, Marco A.; Mote, Patricia A.; Clarke, Christine L.; Stingl, John; Waterhouse, Paul D.; Khokha, Rama (2010). "Progesterone induces adult mammary stem cell expansion". Nature. 465 (7299): 803–807. doi:10.1038/nature09091. ISSN 0028-0836. Khokha, Rama; Murthy, Aditya; Weiss, Ashley (2013). "Metalloproteinases and their natural inhibitors in inflammation and immunity". Nature Reviews Immunology. 13 (9): 649–665. doi:10.1038/nri3499. ISSN 1474-1733. Jackson, Hartland W.; Defamie, Virginie; Waterhouse, Paul; Khokha, Rama (2017). "TIMPs: versatile extracellular regulators in cancer". Nature Reviews Cancer. 17 (1): 38–53. doi:10.1038/nrc.2016.115. ISSN 1474-175X.

Honors and awards In 2014, Khokha was co-recipient of the Robert L. Noble Prize awarded by the Canadian Cancer Society, recognizing her joint work with James Rutka in cancer research.

References

External links Rama Khokha publications indexed by Google Scholar

Worked examples

Example 1 — a first encounter with Rama Khokha

Start with the simplest possible case. Write down what Rama Khokha claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Rama Khokha before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Rama Khokha ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Rama Khokha

In research: Rama Khokha appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Rama Khokha in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Rama Khokha is common in secondary-school and first-year university syllabi. It links to neighbouring topics Canadian cancer researchers, Cancer researchers, Delhi University alumni, so understanding it makes those chapters shorter.
In everyday life: Look for Rama Khokha outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Rama Khokha in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Rama Khokha means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Rama Khokha out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Rama Khokha in simple terms?

Why does Rama Khokha matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Rama Khokha?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Rama Khokha.