science

Robert V. Farese Jr.

Robert V. Farese Jr. is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Robert V. Farese Jr. rather than just read about it. In short: Robert V. Farese Jr., (born October 29, 1959) is an American physician-scientist and professor of Cell Biology at the Sloan Kettering Institute of Memorial Sloan Kettering.

Key takeaways

Robert V. Farese Jr. belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Robert V. Farese Jr. to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Robert V. Farese Jr. from memory before moving on to harder problems.

Reference excerpt

Robert V. Farese Jr., (born October 29, 1959) is an American physician-scientist and professor of Cell Biology at the Sloan Kettering Institute of Memorial Sloan Kettering. He is an internationally recognized leader in the study of cellular lipid metabolism and has made seminal contributions to our understanding of energy storage as triglycerides in cellular organelles called lipid droplets.

Education and career Farese received a B.S. in chemistry from the University of Florida and an M.D. from Vanderbilt University School of Medicine. He completed a residency in internal medicine at the University of Colorado School of Medicine and clinical fellowship in Endocrinology and Metabolism at the University of California, San Francisco (UCSF). His postdoctoral research, in the laboratory of Stephen Young at the Gladstone Institutes, applied genetic models to elucidate the role of apolipoprotein B in cholesterol metabolism and disease. Dr. Farese established his laboratory at the Gladstone Institutes at UCSF, where he made pioneering contributions to the mechanisms of cellular lipid synthesis and storage, cloning the genes for many enzymes of neutral lipid synthesis, including ACAT, DGAT, and MGAT enzymes, and studying their functions in physiology and disease. His laboratory discovered the molecular basis for triglyceride biosynthesis by DGAT1 and DGAT2 enzymes. Upon meeting Dr. Tobias Walther while on sabbatical in Dr. Peter Walter’s lab at UCSF, Farese and Walther began a longstanding collaboration to unravel the biology of cellular lipid droplets, including how lipid droplets are formed, consumed, how proteins target to their surfaces, and the physiological roles these organelles play in biology. Farese and Walther established a joint laboratory at Harvard School of Public Health and Harvard Medical School in 2014. At Harvard School of Public Health, Farese served as Chair of the Department of Molecular Metabolism. In 2022, Farese and Walther moved their laboratory to the Sloan Kettering Institute of Memorial Sloan Kettering. Dr. Farese is a co-founder and board member of the Bluefield Project to Cure Frontotemporal Dementia (FTD) Research. His work has been recognized by a Bristol-Myers Squibb “Freedom to Discover Award,” the ASBMB-Avanti Award in Lipids, the Roy Greep Award for outstanding research of the Endocrine Society, the ASBMB-Merck Award for outstanding research, and by election to the American Society for Clinical Investigation, the Association of American Physicians, and Fellow of the American Society for Cell Biology.

Scientific contributions The Farese laboratory made seminal contributions to the understanding of cellular lipid metabolism. Farese and co-workers, including collaborators at Calgene, discovered the enzymatic basis for triglyceride synthesis via two unrelated enzymes, DGAT1 and DGAT2. Farese's work showed how alterations in lipid synthesis and storage contribute to the pathogenesis of human diseases, in particular type 2 diabetes, liver steatosis, and intestinal fat absorption, and suggested new targets for therapy. Together with Tobias Walther, Farese has pioneered the cell biology of lipid droplets, the cellular organelle responsible for storing triglycerides and metabolic energy. The group has identified hundreds of genes that govern lipid storage in cells, determined the mechanisms of lipid droplet formation in cells, and elucidated principles on how proteins target to lipid droplets, and studies how lipid droplets are turned over. Drs. Farese and Walther also have identified mechanisms of cellular dysfunction that occur in lipid excess, or lipotoxicity. Their lectures on lipid droplet biology are featured in the online iBiology series. The Farese and Walther laboratory also studies lipid metabolism and lysosomal dysfunction in the central nervous system. Research has focused on sphingolipid metabolism and how derangements lead to neurodegeneration and diseases such as FTD or amyotrophic lateral sclerosis.

Awards and honors American Society for Clinical Investigation (1999) Association of American Physicians (2002) Freedom to Discover Award, Bristol Myers Squibb (2005) Avanti Lipid Award, ASBMB (2016) Roy Greep Award for Outstanding Research, Endocrine Society (2018) Elected, Fellow of the American Society of Cell Biology (2020) ASBMB-Merck Award for Outstanding Research in Biochemistry and Molecular Biology (2022)

References

Illustrations

Worked examples

Example 1 — a first encounter with Robert V. Farese Jr.

Start with the simplest possible case. Write down what Robert V. Farese Jr. claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Robert V. Farese Jr. before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Robert V. Farese Jr. ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Robert V. Farese Jr.

In research: Robert V. Farese Jr. appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Robert V. Farese Jr. in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Robert V. Farese Jr. is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1959 births, 20th-century American medical doctors, American scientists, so understanding it makes those chapters shorter.
In everyday life: Look for Robert V. Farese Jr. outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Robert V. Farese Jr. in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Robert V. Farese Jr. means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
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Frequently asked questions

What is Robert V. Farese Jr. in simple terms?

Robert V. Farese Jr., (born October 29, 1959) is an American physician-scientist and professor of Cell Biology at the Sloan Kettering Institute of Memorial Sloan Kettering.

Why does Robert V. Farese Jr. matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Robert V. Farese Jr.?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Robert V. Farese Jr..