science

Romergoline

Romergoline is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Romergoline rather than just read about it. In short: Romergoline (INNTooltip International Nonproprietary Name; developmental code name FCE-23884) is a dopamine receptor modulator of the ergoline family which was under development for the treatment of Parkinson's disease and psychotic disorders but was never marketed. It is closely related to the psychedelic drug LSD in terms of chemical structure, though it is not technically a lysergamide itself as the oxygen atom o…

Key takeaways

Romergoline belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Romergoline to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Romergoline from memory before moving on to harder problems.

Reference excerpt

Romergoline (INNTooltip International Nonproprietary Name; developmental code name FCE-23884) is a dopamine receptor modulator of the ergoline family which was under development for the treatment of Parkinson's disease and psychotic disorders but was never marketed. It is closely related to the psychedelic drug LSD in terms of chemical structure, though it is not technically a lysergamide itself as the oxygen atom of LSD's carboxamide moiety has been removed to instead form an aminomethyl moiety.

Pharmacology

Pharmacodynamics Romergoline shows high affinity for the dopamine D2 receptor (Ki = 6.5 nM), α2-adrenergic receptor (Ki = 4.0 nM), and serotonin 5-HT1A receptor (Ki = 4.0 nM). It also possesses moderate (submicromolar) affinity for the dopamine D1 receptor (Ki = 55 nM) and ketanserin-labeled serotonin 5-HT2 receptor (Ki = 24 nM). Conversely, the drug shows slight or negligible affinity for the α1-adrenergic receptor (Ki = 113 nM), muscarinic acetylcholine receptors (Ki = >10,000 nM), and sigma receptors (Ki = >10,000 nM). Romergoline is said to act as both a dopamine receptor agonist and antagonist, depending on the circumstances. More specifically, the drug is said to act as a D2 receptor silent antagonist under normal dopamine-replete circumstances, but in a dopamine-depleted state, it acts as a powerful dopamine D1 receptor full agonist. This transformation of the drug's activity is thought to be due to development of dopamine D1 receptor supersensitivity with dopamine depletion. Romergoline produces hypolocomotion in rodents and monkeys, inhibits apomorphine-induced climbing behavior in rodents, causes antiemetic effects in dogs, strongly increases prolactin levels in rodents, and antagonizes amphetamine-induced toxicity in rodents. With dopamine depletion however, romergoline induces hyperlocomotion and contralateral turning behavior in 6-hydroxydopamine-lesioned rodents, reverses MPTP-induced akinesia and parkinsonism in monkeys, and reverses reserpine-induced hypokinesia. In any case, in humans, romergoline did not show significant antiparkinsonian effects in a clinical trial.

Pharmacokinetics A metabolite of romergoline is its 6-desmethyl derivative FCE-26506.

History Romergoline was first described in the scientific literature in 1991. It was under development by Pharmacia Corporation, but its development was discontinued by the early 2000s and the drug was never marketed.

See also Substituted ergoline Substituted lysergamides § Related compounds LEK-8829 Acetergamine Metergoline AWD 52-39 FCE-24379

References

Illustrations

Worked examples

Example 1 — a first encounter with Romergoline

Start with the simplest possible case. Write down what Romergoline claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Romergoline before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Romergoline ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Romergoline

In research: Romergoline appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Romergoline in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Romergoline is common in secondary-school and first-year university syllabi. It links to neighbouring topics Abandoned drugs, Adrenergic receptor modulators, D1 receptor agonists, so understanding it makes those chapters shorter.
In everyday life: Look for Romergoline outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Romergoline in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Romergoline means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Romergoline out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Romergoline in simple terms?

Why does Romergoline matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Romergoline?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Romergoline.