biology

Rubredoxin—NAD(+) reductase

Rubredoxin—NAD(+) reductase is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Rubredoxin—NAD(+) reductase rather than just read about it. In short: In enzymology, a rubredoxin-NAD+ reductase (EC 1.18.1.1) is an enzyme that catalyzes the chemical reaction. 2 reduced rubredoxin + NAD+ + H+ ⇌ {\displaystyle \rightleftharpoons } 2 oxidized rubredoxin + NADH The 3 substrates of this enzyme are reduced rubredoxin, NAD+, and H+, whereas its two products are oxidized rubredoxin and NADH. This enzyme belongs to the family of oxidoreductases, specifically those acting on…

Key takeaways

Rubredoxin—NAD(+) reductase belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Rubredoxin—NAD(+) reductase to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Rubredoxin—NAD(+) reductase from memory before moving on to harder problems.

Reference excerpt

In enzymology, a rubredoxin-NAD+ reductase (EC 1.18.1.1) is an enzyme that catalyzes the chemical reaction.

2 reduced rubredoxin + NAD+ + H+ ⇌ {\displaystyle \rightleftharpoons } 2 oxidized rubredoxin + NADH The 3 substrates of this enzyme are reduced rubredoxin, NAD+, and H+, whereas its two products are oxidized rubredoxin and NADH. This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is rubredoxin:NAD+ oxidoreductase. Other names in common use include rubredoxin reductase, rubredoxin-nicotinamide adenine dinucleotide reductase, dihydronicotinamide adenine dinucleotide-rubredoxin reductase, reduced nicotinamide adenine dinucleotide-rubredoxin reductase, NADH-rubredoxin reductase, rubredoxin-NAD reductase, NADH: rubredoxin oxidoreductase, DPNH-rubredoxin reductase, and NADH-rubredoxin oxidoreductase. This enzyme participates in fatty acid metabolism. It has 2 cofactors: FAD and Iron.

Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1BFY.

See also Rubredoxin—NAD(P)(+) reductase

References

Peterson JA, Kusunose M, Kusunose E, Coon MJ (1967). "Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation". J. Biol. Chem. 242 (19): 4334–40. doi:10.1016/S0021-9258(18)99543-8. PMID 4294330. "Enzymatic -oxidation. VI. Isolation of homogeneous reduced diphosphopyridine nucleotide-rubredoxin reductase". J. Biol. Chem. 247 (7): 2109–16. 1972. PMID 4335861. Ueda T, Coon MJ (1972). "Enzymatic oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in hydroxylation". J. Biol. Chem. 247 (16): 5010–6. doi:10.1016/S0021-9258(19)44932-6. PMID 4403503. Petitdemange H, Marczak R, Blusson H, Gay R (1979). "Isolation and properties of reduced nicotinamide adenine dinucleotiderubredoxin oxidoreductase of Clostridium acetobutylicum". Biochem. Biophys. Res. Commun. 91 (4): 1258–65. Bibcode:1979BBRC...91.1258P. doi:10.1016/0006-291X(79)91202-6. PMID 526302.

Worked examples

Example 1 — a first encounter with Rubredoxin—NAD(+) reductase

Start with the simplest possible case. Write down what Rubredoxin—NAD(+) reductase claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Rubredoxin—NAD(+) reductase before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Rubredoxin—NAD(+) reductase ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Rubredoxin—NAD(+) reductase

In research: Rubredoxin—NAD(+) reductase appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Rubredoxin—NAD(+) reductase in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Rubredoxin—NAD(+) reductase is common in secondary-school and first-year university syllabi. It links to neighbouring topics EC 1.18.1, Enzymes of known structure, Flavoproteins, so understanding it makes those chapters shorter.
In everyday life: Look for Rubredoxin—NAD(+) reductase outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

What is Rubredoxin—NAD(+) reductase in simple terms?

In enzymology, a rubredoxin-NAD+ reductase (EC 1.18.1.1) is an enzyme that catalyzes the chemical reaction. 2 reduced rubredoxin + NAD+ + H+ ⇌ {\displaystyle \rightleftharpoons } 2 oxidized rubredoxin + NADH The 3 substrates of this enzyme are reduced rubredoxin, NAD+, and H+, whereas its two produ…

Why does Rubredoxin—NAD(+) reductase matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Rubredoxin—NAD(+) reductase?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Rubredoxin—NAD(+) reductase.