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S1PR4

S1PR4 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand S1PR4 rather than just read about it. In short: Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.

S1PR4 — main illustration
S1PR4 — illustration

Key takeaways

  • S1PR4 belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect S1PR4 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of S1PR4 from memory before moving on to harder problems.

Reference excerpt

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.

Function This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.

Ligands Agonists Sphingosine-1-phosphate CYM50308

Evolution

Paralogues to S1PR4 Gene Source:

S1PR5 S1PR3 S1PR1 S1PR2 LPAR2 LPAR1 LPAR3 CNR1 GPR6 CNR2 GPR3 GPR12 MC4R MC5R MC3R MC2R MC1R GPR119

See also Lysophospholipid receptor

References

Further reading

External links "Lysophospholipid Receptors: S1P4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05. Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Illustrations

S1PR4 illustration
S1PR4 illustration
S1PR4 illustration
S1PR4 illustration
S1PR4 illustration

Worked examples

Example 1 — a first encounter with S1PR4

Start with the simplest possible case. Write down what S1PR4 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to S1PR4 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about S1PR4 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of S1PR4

In research
S1PR4 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses S1PR4 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
S1PR4 is common in secondary-school and first-year university syllabi. It links to neighbouring topics G protein-coupled receptors, Genes on human chromosome 19, Transmembrane receptor stubs, so understanding it makes those chapters shorter.
In everyday life
Look for S1PR4 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study S1PR4 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what S1PR4 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain S1PR4 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is S1PR4 in simple terms?

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.

Why does S1PR4 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study S1PR4?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on S1PR4.

Tags

  • G protein-coupled receptors
  • Genes on human chromosome 19
  • Transmembrane receptor stubs

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