chemistry

SB-247853

SB-247853 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand SB-247853 rather than just read about it. In short: SB-247853 is a highly selective serotonin 5-HT2C receptor inverse agonist which was under development for the treatment of major depressive disorder but was never marketed. Its affinities (Ki) were found to be 0.50 nM for the serotonin 5-HT2C receptor, 60 nM for the serotonin 5-HT2B receptor, and 1,300 nM for the serotonin 5-HT2A receptor.

Key takeaways

SB-247853 belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect SB-247853 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of SB-247853 from memory before moving on to harder problems.

Reference excerpt

SB-247853 is a highly selective serotonin 5-HT2C receptor inverse agonist which was under development for the treatment of major depressive disorder but was never marketed. Its affinities (Ki) were found to be 0.50 nM for the serotonin 5-HT2C receptor, 60 nM for the serotonin 5-HT2B receptor, and 1,300 nM for the serotonin 5-HT2A receptor. Hence, it shows 120-fold selectivity for the serotonin 5-HT2C receptor over the serotonin 5-HT2B receptor and 2,600-fold selectivity for the serotonin 5-HT2C receptor over the serotonin 5-HT2A receptor. The drug reverses the hypolocomotion induced by the serotonin 5-HT2C receptor agonist meta-chlorophenylpiperazine (mCPP) in rodents. It is orally active. The drug produced orthostatic intolerance in healthy human volunteers during the first dose-escalation clinical study. Subsequently, it was found to cause substantial hypotension (low blood pressure) and presyncope (pre-fainting symptoms) in the tilt table test. It was concluded based on these findings that the serotonin 5-HT2C receptor is involved in regulating the cardiovascular system. SB-247853 was first described in the scientific literature by 2000. It was developed by GlaxoSmithKline. The drug reached phase 1 clinical trials prior to the discontinuation of its development in 2005.

See also Serotonin 5-HT2C receptor antagonist List of investigational antidepressants

References

Illustrations

Worked examples

Example 1 — a first encounter with SB-247853

Start with the simplest possible case. Write down what SB-247853 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to SB-247853 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about SB-247853 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of SB-247853

In research: SB-247853 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses SB-247853 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: SB-247853 is common in secondary-school and first-year university syllabi. It links to neighbouring topics 5-HT2C antagonists, Abandoned drugs, Antihypertensive agents, so understanding it makes those chapters shorter.
In everyday life: Look for SB-247853 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study SB-247853 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what SB-247853 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain SB-247853 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is SB-247853 in simple terms?

Why does SB-247853 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study SB-247853?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on SB-247853.