science

SDMA (drug)

SDMA (drug) is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand SDMA (drug) rather than just read about it. In short: SDMA, also known as 3,4-methylenethiooxy-N-methylamphetamine (3T-MDMA) or as MY100, is a putative entactogen of the phenethylamine and amphetamine families related to 3,4-methylenedioxy-N-methylamphetamine (MDMA). It is the analogue of MDMA in which the oxygen atom at the 3 position within the 3,4-methylenedioxy substitution has been replaced with a sulfur atom to give a 1,3-benzoxathiole rather than 1,3-benzodioxol…

Key takeaways

SDMA (drug) belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect SDMA (drug) to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of SDMA (drug) from memory before moving on to harder problems.

Reference excerpt

SDMA, also known as 3,4-methylenethiooxy-N-methylamphetamine (3T-MDMA) or as MY100, is a putative entactogen of the phenethylamine and amphetamine families related to 3,4-methylenedioxy-N-methylamphetamine (MDMA). It is the analogue of MDMA in which the oxygen atom at the 3 position within the 3,4-methylenedioxy substitution has been replaced with a sulfur atom to give a 1,3-benzoxathiole rather than 1,3-benzodioxole ring system. The drug is also the N-methyl derivative of 3,4-methylenethiooxyamphetamine (SDA; 3T-MDA). SDMA is of interest for potential therapeutic use.

Interactions

Pharmacology

Pharmacodynamics Similarly to MDMA, SDMA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) and a non-selective serotonin 5-HT2 receptor agonist. However, SDMA was 11-fold more potent as a serotonin releaser, 19-fold more potent as a dopamine releaser, and 2-fold more potent as a norepinephrine releaser than MDMA in HEK293 cells in vitro. In addition, it was about twice as potent as a serotonin 5-HT2A receptor agonist, whereas it showed similar agonistic potency as MDMA at the serotonin 5-HT2B and 5-HT2C receptors. SDMA had similar activational efficacies at the serotonin 5-HT2 receptors as MDMA. Due to its greater potency as a monoamine releasing agent, SDMA may be active at lower doses or concentrations than MDMA. SDMA produced hyperlocomotion and hyperthermia in rodents with similar profiles as MDMA. However, SDMA did not produce rewarding effects in the conditioned place preference (CPP) paradigm unlike MDMA. Hence, SDMA might have reduced misuse potential compared to MDMA. As with MDMA, SDMA did not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and hence may not produce hallucinogenic effects in humans. SDMA might be less cardiotoxic than MDMA due to having much greater monoamine-releasing potency but unaltered serotonin 5-HT2B receptor agonistic potency.

Pharmacokinetics The metabolism and metabolites of SDMA have been studied. It showed more rapid clearance than MDMA in rodents and hence may have a shorter elimination half-life and/or duration.

Chemistry

Synthesis The chemical synthesis of SDMA has been described.

Analogues A notable analogue of SDMA is 4T-MMDA-2 (2-methoxy-4T-MDA), which was described by Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved). Other analogues of SDMA include SDA, MDMA, 5-MAPB, and 6-MAPBT, among others.

History SDMA was first mentioned in the scientific literature by 2013, but was only conceptually described at this time. Subsequently, its synthesis and preclinical pharmacology were described by Nina Kastner and colleagues including Matthias Grill at MiHKAL in 2025. In addition, SDMA was patented by Mydecine as a shorter-acting MDMA alternative in 2023. Prodrugs of SDMA and/or related compounds have also been described. The drug is of interest for potential therapeutic use, for instance treatment of post-traumatic stress disorder (PTSD).

See also Substituted methylenedioxyphenethylamine § Related compounds List of investigational hallucinogens and entactogens

References

External links SDMA - Isomer Design

Illustrations

Worked examples

Example 1 — a first encounter with SDMA (drug)

Start with the simplest possible case. Write down what SDMA (drug) claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to SDMA (drug) before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about SDMA (drug) ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of SDMA (drug)

In research: SDMA (drug) appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses SDMA (drug) in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: SDMA (drug) is common in secondary-school and first-year university syllabi. It links to neighbouring topics 5-HT2A agonists, 5-HT2B agonists, 5-HT2C agonists, so understanding it makes those chapters shorter.
In everyday life: Look for SDMA (drug) outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study SDMA (drug) in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what SDMA (drug) means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain SDMA (drug) out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is SDMA (drug) in simple terms?

Why does SDMA (drug) matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study SDMA (drug)?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on SDMA (drug).