Septin-2 (also known as SEPT2) is a protein which in humans is encoded by the SEPTIN2 gene (previously SEPT2).
Function SEPT2 can hetero-oligomerize with SEPT6 and SEPT7 to form filaments. SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain. Knockdown of SEPT2, SEPT6, and SEPT7 in causes actin stress fibers to disintegrate and cells to lose polarity. Septins, SOCS7, and NCK1 are part of a signaling pathway that ties regulation of the DNA damage response to the cytoskeleton.
Interactions SEPT2 has been shown to interact with:
SEPT6 SEPT7, and SEPT9.
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