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biology

SH3TC2

SH3TC2 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand SH3TC2 rather than just read about it. In short: SH3 domain and tetratricopeptide repeats-containing protein 2 is a protein that in humans is encoded by the SH3TC2 gene. It is believed to be expressed in the Schwann cells that wrap the myelin sheath around nerves.

SH3TC2 — main illustration
SH3TC2 — illustration

Key takeaways

  • SH3TC2 belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect SH3TC2 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of SH3TC2 from memory before moving on to harder problems.

Reference excerpt

SH3 domain and tetratricopeptide repeats-containing protein 2 is a protein that in humans is encoded by the SH3TC2 gene. It is believed to be expressed in the Schwann cells that wrap the myelin sheath around nerves.

Function This gene encodes a protein with two N-terminal Src homology 3 (SH3) domains and 10 tetratricopeptide repeat (TPR) motifs, and is a member of a small gene family. The gene product has been proposed to be an adapter or docking molecule. The mouse version (orthologue) of SH3TC2 is believed to be expressed in Schwann cells. The tagged protein localizes to the plasma membrane and to the perinuclear endocytic recycling compartment. Mice lacking Sh3tc2 have an abnormal organization of the node of Ranvier consistent with the idea that the protein might have a role in myelination or in axon – glial cell interactions.

Clinical significance Mutations in SH3TC2 are known to cause the following conditions:

Charcot-Marie-Tooth disease type 4C, an autosomal recessive childhood-onset neurodegenerative disease characterized by demyelination of motor and sensory neurons; Mononeuropathy of the median nerve (MNMN) at the wrist.

References

Further reading

External links GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4 GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4C

Illustrations

SH3TC2 illustration
SH3TC2 illustration
SH3TC2 illustration
SH3TC2 illustration
SH3TC2 illustration

Worked examples

Example 1 — a first encounter with SH3TC2

Start with the simplest possible case. Write down what SH3TC2 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to SH3TC2 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about SH3TC2 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of SH3TC2

In research
SH3TC2 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses SH3TC2 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
SH3TC2 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 5, Human chromosome 5 gene stubs, so understanding it makes those chapters shorter.
In everyday life
Look for SH3TC2 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study SH3TC2 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what SH3TC2 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain SH3TC2 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is SH3TC2 in simple terms?

SH3 domain and tetratricopeptide repeats-containing protein 2 is a protein that in humans is encoded by the SH3TC2 gene. It is believed to be expressed in the Schwann cells that wrap the myelin sheath around nerves.

Why does SH3TC2 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study SH3TC2?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on SH3TC2.

Tags

  • Genes on human chromosome 5
  • Human chromosome 5 gene stubs

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